HoxD12 Inhibitors
HoxD12 Inhibitors are a class of chemical compounds that specifically target and modulate the activity of the HoxD12 gene. HoxD12 is a member of the Hox gene family, which plays a crucial role in embryonic development and pattern formation in various organisms, including humans. These inhibitors are designed to interfere with the normal function of HoxD12 by binding to specific molecular targets associated with its regulation and expression.
The HoxD12 gene is known for its involvement in the formation of specific body structures during early development, particularly in the context of limb development and segmentation. Hox genes, including HoxD12, encode transcription factors that control the expression of downstream genes responsible for determining the identity and positioning of different body parts along the anterior-posterior axis. HoxD12 Inhibitors are developed to selectively interact with the regulatory elements of HoxD12, disrupting its transcriptional activity or inhibiting its binding to essential cofactors. This interference can lead to altered patterns of gene expression during development, potentially resulting in abnormal limb formation or other structural changes. The study and manipulation of HoxD12 Inhibitors hold promise for gaining insights into the molecular mechanisms underlying embryonic development and may have applications in research related to developmental biology and genetics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
An inhibitor of DNA methyltransferases, which can alter gene expression patterns including those of homeobox genes. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that inhibits transcription factors and can disrupt multiple signaling pathways involved in cellular regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that can change the chromatin structure, thereby potentially influencing HOXD12 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound from turmeric that can modulate a variety of signaling pathways and potentially alter transcription factor activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound that can modulate sirtuin activity and impact gene expression, including potentially that of homeobox genes. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
An inhibitor of the Hedgehog (Hh) signaling pathway which can affect the expression of multiple genes, possibly including homeobox genes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that can affect cell growth and proliferation, potentially influencing the expression of homeobox genes. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
A gamma-secretase inhibitor that can affect Notch signaling, which is intertwined with the regulation of many genes, including homeobox genes. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that can alter cell structure and function, potentially affecting gene expression profiles. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A MEK inhibitor that blocks the MAPK/ERK pathway, potentially altering the expression of genes regulated by this pathway. | ||||||