HoxB5 Inhibitors
Chemical inhibitors of HoxB5 function by disrupting specific signaling pathways that regulate the activity of this protein during developmental processes. Cyclopamine and Jervine, both steroidal alkaloids, directly bind to and inhibit the Smoothened (SMO) receptor, a critical component of the Hedgehog (Hh) signaling pathway. This inhibition prevents the pathway from activating and carrying out its downstream effects, which include the regulation of HoxB5 activity. Similarly, Vismodegib, LDE225 (Sonidegib), Saridegib, Taladegib, and PF-04449913 are all small molecule inhibitors that target the Smoothened receptor. By binding to Smoothened, these inhibitors disrupt the Hedgehog signaling pathway, which is necessary for the proper functioning of HoxB5. The interruption of this signaling cascade leads to a decrease in HoxB5 function, as the pathway cannot proceed to activate the necessary genes involved in development.
Itraconazole, although known primarily as an antifungal agent, also demonstrates inhibitory effects on the Smoothened receptor, thus impacting the Hedgehog pathway and consequently the activity of HoxB5. SANT-1 is an antagonist of the Smoothened receptor and serves to inhibit the Hedgehog signaling pathway. Its action prevents the activation of downstream genes regulated by the pathway, thereby inhibiting the functional activity of HoxB5. GANT61, on the other hand, targets the GLI family of transcription factors, which are downstream effectors in the Hedgehog pathway. The inhibition of GLI by GANT61 disrupts the expression of target genes under the control of Hedgehog signaling, thus leading to a functional inhibition of HoxB5. All these chemicals act by intervening in the biochemical signaling pathway that HoxB5 is a part of, which leads to the functional inhibition of the protein's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a steroidal alkaloid that specifically inhibits the Hedgehog (Hh) signaling pathway, which is involved in the regulation of developmental processes. HoxB5 is known to be regulated by Hh signaling during development. Cyclopamine binding to Smoothened (SMO) receptor leads to the inhibition of the pathway, thereby potentially inhibiting the function of HoxB5 by preventing its downstream effects. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT61 is a small molecule inhibitor of the GLI family of transcription factors, which are the downstream effectors in the Hedgehog pathway. By inhibiting GLI, GANT61 would disrupt the expression of HoxB5, which is regulated by the Hedgehog pathway, thus leading to a functional inhibition of HoxB5. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine, like Cyclopamine, is a steroidal alkaloid that antagonizes the Hedgehog signaling pathway by binding to the Smoothened receptor. Its inhibition of the Hh pathway would lead to a decrease in HoxB5 function due to the reliance of HoxB5 on this pathway for its expression and regulatory functions during development. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Vismodegib is an inhibitor of the Smoothened receptor, a key component of the Hedgehog signaling pathway. By inhibiting Smoothened, Vismodegib would disrupt the Hedgehog pathway and thereby inhibit the functional activities of HoxB5 that are regulated by this pathway. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $76.00 $139.00 | 23 | |
Itraconazole has been shown to inhibit the Hedgehog signaling pathway by interacting with the Smoothened receptor. Through this inhibition, it can indirectly inhibit HoxB5 functions that are regulated by the Hh pathway during developmental processes. | ||||||
Saridegib | 1037210-93-7 | sc-507351 | 5 mg | $3500.00 | ||
Saridegib is a potent inhibitor of the Smoothened receptor, thereby inhibiting the Hedgehog pathway. This pathway is crucial for the regulation of HoxB5, and its inhibition by Saridegib would lead to a decrease in functional HoxB5 activity. | ||||||
Glasdegib | 1095173-27-5 | sc-507353 | 5 mg | $165.00 | ||
PF-04449913 is a selective inhibitor of the Smoothened receptor. By inhibiting this receptor, it would disrupt the Hedgehog pathway and subsequently the function of HoxB5 that is regulated by this pathway. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $132.00 | 5 | |
SANT-1 acts as a potent antagonist of the Smoothened receptor within the Hedgehog signaling pathway. By preventing the activation of this pathway, SANT-1 would functionally inhibit HoxB5's role in development as regulated by Hedgehog signaling. | ||||||