HoxB5 Antibody (133C3a): sc-81099

HoxB5 Antibody (133C3a) is a mouse monoclonal IgG1 antibody that detects HoxB5 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-HoxB5 antibody (133C3a) is available as a non-conjugated format. HoxB5 protein, also known as homeobox protein Hox-B5, HOX2, HU-1, HOX2A, Hox2.1, or HHO.C10, is a crucial member of the Antp homeobox (Hox) family, consisting of 269 amino acids and primarily expressed in the central nervous system. HoxB5 contains a homeobox DNA-binding domain, which is essential for function as a transcription factor that regulates gene expression during development. HoxB5 plays a significant role in lung and gut development, providing cells with positional identities along the anterior-posterior body axis. Precise regulation of HoxB5 is vital, as HoxB5 influences axial patterning and is implicated in various developmental processes, including the formation of specific anatomical structures. Aberrations in HoxB5 expression have been associated with leukemias and hereditary malformations, highlighting importance in both normal development and disease.

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HoxB5 Antibody (133C3a) References:

1. [Influence of human cytomegalovirus infection on the expressions of HOXB1, HOXB5, HOXB6, and HOXB9 genes in human embryo lung cells].  |  Chen, LY., et al. 2001. Hunan Yi Ke Da Xue Xue Bao. 26: 189-91. PMID: 12536675
2. HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.  |  Wu, Y., et al. 2003. Mol Cell Biol. 23: 5680-91. PMID: 12897140
3. HOXB5 expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblasts.  |  Fu, M., et al. 2003. Dev Dyn. 228: 1-10. PMID: 12950074
4. Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age.  |  Korshunov, A., et al. 2003. Am J Pathol. 163: 1721-7. PMID: 14578171
5. Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype.  |  Neben, K., et al. 2005. Oncogene. 24: 1580-8. PMID: 15674343
6. Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1).  |  Lind, GE., et al. 2006. J Pathol. 210: 441-9. PMID: 17029216
7. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.  |  Wu, Q., et al. 2007. Mol Cancer. 6: 45. PMID: 17623056
8. Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos.  |  Sakach, M. and Safaei, R. 1996. Int J Dev Neurosci. 14: 567-73. PMID: 8930688

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxB5 Antibody (133C3a) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxB5 Antibody (133C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxB5 Antibody (133C3a) Specifications

Alternate Product Name: HoxB5

Product Clone Name: 133C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HoxB5

Epitope Species: human

Product Reactivity/Detection: HoxB5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for HoxB5 Antibody (133C3a): N/A