Hop2 Inhibitors
Hop2 inhibitors are a class of chemical compounds that target and inhibit the activity of the Hop2 protein. Hop2, along with Mnd1, forms a protein complex that plays a critical role in homologous recombination, a process crucial for the repair of double-strand breaks in DNA. Homologous recombination relies on the accurate pairing of homologous chromosomes, and Hop2 is essential in promoting this synapsis by stabilizing and facilitating the strand invasion step. Specifically, Hop2 helps in the alignment and annealing of single-stranded DNA with homologous double-stranded DNA. Inhibitors of Hop2 disrupt these key interactions, resulting in interference with the homologous recombination process. These inhibitors are often utilized to study the molecular mechanics of DNA repair and recombination.
By interfering with the Hop2-Mnd1 complex, Hop2 inhibitors can affect various cellular processes dependent on precise DNA repair and recombination. Researchers often use these compounds in experimental settings to gain insights into the dynamics of homologous recombination pathways and to explore how cells respond to DNA damage when key recombination proteins are inactivated. Additionally, Hop2 inhibitors provide a valuable tool for understanding the roles of other proteins that work in conjunction with Hop2, such as Rad51 and Dmc1, which are involved in strand invasion and exchange. This inhibition can lead to the accumulation of DNA breaks or faulty recombination, providing a model system for studying genome integrity and the biochemical pathways involved in DNA repair mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin is an antitumor antibiotic that can inhibit DNA synthesis and cause DNA damage. Hop2 is involved in DNA repair and recombination processes. By inducing DNA damage, Bleomycin can potentially inhibit the function of Hop2 by interfering with its role in DNA repair and recombination. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a platinum-based chemotherapy compound that forms DNA adducts and crosslinks, leading to DNA damage. Hop2 is involved in DNA repair processes, and cisplatin-induced DNA damage can potentially interfere with the function of Hop2 in DNA repair and recombination. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE 821 is a selective inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a key regulator of the DNA damage response pathway. Hop2 is involved in DNA repair processes that are regulated by ATR kinase. By inhibiting ATR kinase with VE 821, it can potentially disrupt the signaling pathway that regulates Hop2, leading to impaired DNA repair and recombination function. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib is a poly(ADP-ribose) polymerase (PARP) inhibitor that prevents the repair of DNA damage, particularly in cells with defective DNA repair mechanisms. Hop2 is involved in DNA repair processes, and by inhibiting PARP with Olaparib, it can potentially impair the repair function of Hop2 and lead to the accumulation of DNA damage. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide (VP-16) is a topoisomerase II inhibitor that can trap the enzyme-DNA complex, leading to DNA damage and strand breaks. Hop2 is involved in DNA repair processes, and etoposide-induced DNA damage can potentially interfere with the function of Hop2 in DNA repair and recombination. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU 7441 is a selective inhibitor of DNA-dependent protein kinase (DNA-PK), a key enzyme involved in DNA repair processes. Hop2 is involved in DNA repair and recombination, which can be regulated by DNA-PK. By inhibiting DNA-PK with NU 7441, it can potentially disrupt the signaling pathway that regulates Hop2, leading to impaired DNA repair and recombination function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a natural alkaloid that inhibits topoisomerase I, an enzyme involved in DNA replication and repair. By inhibiting topoisomerase I, camptothecin can potentially disrupt the function of Hop2 in DNA repair and recombination. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a natural antibiotic that inhibits DNA polymerase α, δ, and ε, enzymes involved in DNA replication. Hop2 is involved in DNA repair processes that require DNA polymerases. By inhibiting DNA polymerases with aphidicolin, it can potentially interfere with the function of Hop2 in DNA repair and recombination. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
ATM Kinase Inhibitor is a selective inhibitor of ataxia telangiectasia mutated (ATM) kinase, a key regulator of the DNA damage response pathway. Hop2 is involved in DNA repair processes that are regulated by ATM kinase. By inhibiting ATM kinase with ATM Kinase Inhibitor, it can potentially disrupt the signaling pathway that regulates Hop2, leading to impaired DNA repair and recombination function. | ||||||
RAD51 Inhibitor B02 | 1290541-46-6 | sc-507533 | 10 mg | $95.00 | ||
B02 is a small molecule inhibitor of RAD51, a key protein involved in homologous recombination, a process in which Hop2 plays a role. By inhibiting RAD51 with B02, it can potentially disrupt the function of Hop2 in homologous recombination. | ||||||