HOOK1 Activators
HOOK1 Activators encompass a spectrum of chemical compounds that indirectly augment the functional activity of HOOK1 through discrete cellular mechanisms and signaling pathways. Compounds like Forskolin and Phorbol 12-myristate 13-acetate (PMA) enhance HOOK1's role in microtubule organization by increasing the activity of protein kinases such as PKA and PKC, respectively. These kinases can phosphorylate substrates that may affect the microtubule-organizing center, thereby facilitating HOOK1's tethering and organelle positioning capabilities. Similarly, by inhibiting protein phosphatases, Calyculin A and Okadaic Acid could maintain HOOK1 in a phosphorylated state, which is crucial for its activation and stability within the cellular cytoskeleton. Lithium Chloride and Epigallocatechin Gallate (EGCG) provide another layer of regulation by modulating kinase activities, such as GSK-3, which in turn may enhance HOOK1's microtubule stabilization functions.
Further indirect activation of HOOK1 is achieved through the modulation of cytoskeletal dynamics and organization by compounds like Sphingosine-1-phosphate, BI-D1870, Y-27632, and ML141. Sphingosine-1-phosphate, through its lipid signaling properties, can lead to cytoskeletal rearrangements that enhance the role of HOOK1 in microtubule organization. BI-D1870, by inhibiting RSK kinases, and Y-27632, as a ROCK inhibitor, influence actin dynamics and cellular morphology, indirectly supporting HOOK1's microtubule-related activities. ML141's inhibition of Cdc42 GTPase also plays a role in modulating the cellular architecture that can amplify HOOK1's functions. Collectively, these activators, through their targeted effects on various signaling molecules and pathways, serve to potentiate the microtubule-associated functions of HOOK1.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which can lead to activation of PKA. PKA can then phosphorylate proteins including those in the microtubule-organizing center, where HOOK1 is known to localize, potentially enhancing HOOK1's role in microtubule tethering and organelle positioning. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in various signaling pathways. Activation of PKC can lead to changes in cytoskeletal organization, which may indirectly increase the functional activity of HOOK1 in microtubule anchoring. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor that prevents dephosphorylation of proteins, thereby potentially maintaining HOOK1 in a phosphorylated state which may be required for its activation or stabilization within the cellular cytoskeleton. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell that can indirectly enhance HOOK1 function by affecting its phosphorylation state. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase that can phosphorylate various substrates. Inhibition of GSK-3 alters microtubule dynamics and stability, which could conceivably enhance the microtubule tethering function of HOOK1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG has multiple effects on cellular pathways, including inhibition of certain kinases. This can alter the cytoskeletal dynamics and could potentially enhance the role of HOOK1 in microtubule organization. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate is a lipid signaling molecule that can activate S1P receptors and downstream signaling pathways, potentially influencing cytoskeletal rearrangement and thus the activity of HOOK1. | ||||||
BI-D1870 | 501437-28-1 | sc-397022 sc-397022A | 1 mg 5 mg | $90.00 $275.00 | 12 | |
BI-D1870 is an inhibitor of RSK (p90 ribosomal S6 kinase), which upon inhibition could alter the phosphorylation patterns of proteins associated with microtubule dynamics, thereby potentially enhancing HOOK1's activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that can influence cytoskeletal organization and cell morphology. By affecting actin dynamics, this compound might indirectly enhance HOOK1's function related to microtubule organization. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
ML 141 is a potent and selective inhibitor of Cdc42 GTPase. By influencing Cdc42 activity, ML141 could affect cytoskeletal organization and thus potentially enhance HOOK1's role in microtubule-based processes. | ||||||