Date published: 2025-12-5

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Homobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of homobifunctional crosslinkers for use in various applications. Homobifunctional crosslinkers are chemical reagents that possess two identical reactive groups, enabling them to covalently link two similar functional groups within or between molecules. These crosslinkers are crucial in scientific research for studying protein-protein interactions, stabilizing protein structures, and creating multi-subunit complexes. Researchers utilize homobifunctional crosslinkers to investigate the spatial organization and dynamics of macromolecular assemblies, providing insights into the structural and functional relationships within biological systems. These crosslinkers are also employed in the development of biomaterials, where they enhance the mechanical properties and stability of synthetic polymers and hydrogels. In addition, homobifunctional crosslinkers play a significant role in immobilizing enzymes and other bioactive molecules onto solid supports, facilitating their use in biosensors, bioassays, and biocatalysis. By offering a comprehensive selection of high-quality homobifunctional crosslinkers, Santa Cruz Biotechnology supports advanced research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving innovations in the understanding of molecular interactions and the development of new biotechnological applications. View detailed information on our available homobifunctional crosslinkers by clicking on the product name.

Items 11 to 20 of 60 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Suberate Bis(sulfosuccinimidyl) Sodium Salt

127634-19-9sc-220138
100 mg
$266.00
(1)

Suberate Bis(sulfosuccinimidyl) Sodium Salt is a homobifunctional reagent known for its dual reactive sites, which facilitate cross-linking through amine interactions. Its unique sulfosuccinimidyl groups enhance reactivity, promoting efficient conjugation and stabilization of biomolecules. The compound's ability to form stable linkages under mild conditions allows for precise control in complex molecular assemblies. Additionally, its solubility in aqueous environments supports diverse experimental setups, making it a versatile tool in chemical synthesis.

p-Phenylene diisothiocyanate

4044-65-9sc-250628
1 g
$32.00
(0)

p-Phenylene diisothiocyanate is a homobifunctional compound characterized by its two isothiocyanate groups, which enable selective reactions with nucleophiles, particularly amines and thiols. This reactivity facilitates the formation of stable thiourea linkages, promoting robust cross-linking in polymer networks. Its unique structure allows for regioselective modifications, enhancing the complexity of molecular architectures. The compound's stability under various conditions makes it suitable for diverse synthetic pathways, contributing to its utility in advanced material science.

1,3-Propanediyl Bismethanethiosulfonate

55-96-9sc-208779
25 mg
$372.00
(0)

1,3-Propanediyl Bismethanethiosulfonate is a homobifunctional compound featuring two methanethiosulfonate groups that engage in nucleophilic substitution reactions. This dual functionality allows for the formation of disulfide bonds, promoting intricate cross-linking in polymer systems. Its unique reactivity profile enables selective interactions with thiols, facilitating the construction of complex molecular frameworks. The compound's stability and versatility in reaction conditions make it a valuable tool for exploring diverse synthetic strategies.

1,4-Butanediyl Bismethanethiosulfonate

55-99-2sc-208789
25 mg
$330.00
2
(0)

1,4-Butanediyl Bismethanethiosulfonate is a homobifunctional compound characterized by its two methanethiosulfonate moieties, which enable efficient thiol-mediated reactions. This compound exhibits a propensity for forming robust disulfide linkages, enhancing structural integrity in various materials. Its distinctive reactivity allows for precise modulation of molecular architectures, while its compatibility with diverse reaction environments supports innovative synthetic approaches.

1,6-Hexanediyl Bismethanethiosulfonate

56-01-9sc-208808
25 mg
$330.00
(0)

1,6-Hexanediyl Bismethanethiosulfonate is a homobifunctional compound featuring dual methanethiosulfonate groups that facilitate selective cross-linking through thiol exchange reactions. This compound demonstrates unique reactivity patterns, promoting the formation of stable thioether bonds. Its extended chain structure enhances flexibility and spatial arrangement, allowing for tailored interactions in polymer networks and enabling the design of complex molecular architectures with specific functional properties.

Adipic acid dihydrazide

1071-93-8sc-257072
25 g
$105.00
1
(0)

Adipic acid dihydrazide is a homobifunctional compound characterized by its two hydrazide groups, which enable efficient formation of hydrazone linkages through condensation reactions. This compound exhibits notable reactivity with carbonyl-containing compounds, facilitating the creation of stable networks. Its symmetrical structure promotes uniform distribution in polymer matrices, enhancing mechanical properties and enabling precise control over cross-linking density, thus influencing the material's overall performance.

1,4-Phenylene-bis-maleimide

3278-31-7sc-208795
5 g
$165.00
(0)

1,4-Phenylene-bis-maleimide is a homobifunctional compound featuring two maleimide groups that engage in Michael addition reactions with nucleophiles, leading to the formation of robust covalent bonds. Its unique structure allows for selective cross-linking, enhancing thermal stability and mechanical strength in polymer systems. The compound's ability to undergo rapid reaction kinetics under mild conditions facilitates the development of tailored materials with specific properties, making it a versatile building block in polymer chemistry.

N,N′-Ethylenebis(iodoacetamide)

7250-43-3sc-215511
100 mg
$438.00
5
(0)

N,N'-Ethylenebis(iodoacetamide) is a homobifunctional reagent characterized by its two iodoacetamide groups, which readily form covalent bonds with nucleophilic sites, such as thiols and amines. This compound exhibits a high reactivity profile, enabling efficient cross-linking and modification of biomolecules. Its unique bifunctional nature allows for precise control over molecular architecture, facilitating the design of complex networks and enhancing the stability of conjugated systems.

1,2-Phenylene-bis-maleimide

13118-04-2sc-208752
5 g
$209.00
(0)

1,2-Phenylene-bis-maleimide is a homobifunctional compound featuring two maleimide groups that engage in selective Michael addition reactions with thiol-containing molecules. This reactivity allows for the formation of stable thioether linkages, promoting robust cross-linking in polymer matrices. Its unique structure enhances the formation of tailored networks, influencing the mechanical properties and thermal stability of the resulting materials, while also enabling precise spatial arrangement of functional groups.

N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester

21994-89-8sc-212275
sc-212275A
sc-212275B
sc-212275C
sc-212275D
25 mg
100 mg
250 mg
1 g
10 g
$120.00
$204.00
$280.00
$1062.00
$10210.00
(1)

N-Succinimidoxycarbonyl-β-alanine N-Succinimidyl Ester is a homobifunctional reagent characterized by its ability to form stable amide bonds through nucleophilic attack by amines. This compound exhibits a high reactivity profile, facilitating efficient conjugation reactions that can be finely tuned by varying reaction conditions. Its unique structure allows for selective targeting of functional groups, promoting the formation of complex molecular architectures and enhancing the specificity of interactions in biochemical applications.