N,Nprime-Ethylenebis(iodoacetamide) CAS: 7250-43-3
MF: C6H10I2N2O2
MW: 395.96
A homobifunctional sulfhydryl-reactive crosslinker.

N,N′-Ethylenebis(iodoacetamide) (CAS 7250-43-3)

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Alternate Names: N,N'-1,2-ethanediylbis(2-iodoacetamide); EBI
Application: N,N′-Ethylenebis(iodoacetamide) is A homobifunctional sulfhydryl-reactive crosslinker
CAS Number: 7250-43-3
Purity: ≥95%
Molecular Weight: 395.96
Molecular Formula: C6H10I2N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

N,N'-Ethylenebis(iodoacetamide) is a homobifunctional sulfhydryl-reactive crosslinker. It has been used to conjugate groups in tubulin and can therefore be used as a probe for the conformational state of the tubulin molecule.


References

Luduena, R.F., et al.: Biochemistry, 20, 4437 (1981), Sullivan, K.F.: Ann. Rev. Cell Biology, 4, 687 (1988), Sharma, J., et al.: Journal of Protein Chemistry, 13, 2, 165 (1994)

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
Storage :
Store at -20° C
Melting Point :
>205° C (dec.)
Boiling Point :
548.90° C at 760 mmHg (Predicted)
Density :
2.24 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
pK Values :
pKa: 13.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
AB8760000
PubChem CID :
23678
MDL Number :
MFCD00728185
Beilstein Registry :
2444246
SMILES :
C(CNC(=O)CI)NC(=O)CI

Download SDS (MSDS)

Certificate of Analysis

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N,Nprime-Ethylenebis(iodoacetamide) (CAS 7250-43-3)  Product Citations

See how others have used N,Nprime-Ethylenebis(iodoacetamide) (CAS 7250-43-3). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27689728  Meegan, MJ. et al. 2017. Eur J Med Chem. 125: 453-463.

PMID: # 26680364  Greene, TF. et al. 2016. J. Med. Chem. 59: 90-113.

PMID: # 30979033  Pharmaceuticals (Basel).

Citations 1 to 3 of 3 total

solubility of this compound

Asked by: Faiza
The solubility of the product is as slightly soluble in DMSO, and slightly in DCM. When we say ‘Slightly’ soluble, that means that between 1-10 mg of the product is able to dissolve in 1 ml of the specified solvent. So, solubility should be quite well in these two solvents.
Answered by: Technical Support
Date published: 2019-11-27
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