Date published: 2025-12-5

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1,6-Hexanediyl Bismethanethiosulfonate (CAS 56-01-9)

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Alternate Names:
Methanesulfonothioic Acid S,S′-1,6-Hexanediyl Ester; 1,6-Hexanedithiol Dimethanesulfonate
Application:
1,6-Hexanediyl Bismethanethiosulfonate is a homobifunctional sulfhydryl-reactive crosslinker
CAS Number:
56-01-9
Molecular Weight:
306.49
Molecular Formula:
C8H18O4S4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1,6-Hexanediyl Bismethanethiosulfonate is a homobifunctional sulfhydryl-reactive crosslinker.


1,6-Hexanediyl Bismethanethiosulfonate (CAS 56-01-9) References

  1. Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers.  |  Loo, TW. and Clarke, DM. 2001. J Biol Chem. 276: 36877-80. PMID: 11518701
  2. Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site.  |  Loo, TW. and Clarke, DM. 2002. Proc Natl Acad Sci U S A. 99: 3511-6. PMID: 11891276
  3. Helix packing of the cardiac Na+-Ca2+ exchanger: proximity of transmembrane segments 1, 2, and 6.  |  Ren, X., et al. 2006. J Biol Chem. 281: 22808-14. PMID: 16785232
  4. Transmembrane segments I, II, and VI of the canine cardiac Na+/Ca2+ exchanger are in proximity.  |  Ren, X., et al. 2007. Ann N Y Acad Sci. 1099: 40-2. PMID: 17332072
  5. Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels.  |  Nair, AV., et al. 2009. Eur Biophys J. 38: 993-1002. PMID: 19488745
  6. Residues gating the periplasmic pathway of LacY.  |  Zhou, Y., et al. 2009. J Mol Biol. 394: 219-25. PMID: 19781551
  7. Cystathionine β-synthase (CBS) domains 1 and 2 fulfill different roles in ionic strength sensing of the ATP-binding cassette (ABC) transporter OpuA.  |  Karasawa, A., et al. 2011. J Biol Chem. 286: 37280-91. PMID: 21878634
  8. Cross-linking-based flexibility and proximity relationships between the TM segments of the Escherichia coli YidC.  |  Hennon, SW. and Dalbey, RE. 2014. Biochemistry. 53: 3278-86. PMID: 24801559
  9. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6.  |  Wilson, MR., et al. 2015. Biochem J. 469: 33-44. PMID: 25877470
  10. Constraining the Lateral Helix of Respiratory Complex I by Cross-linking Does Not Impair Enzyme Activity or Proton Translocation.  |  Zhu, S. and Vik, SB. 2015. J Biol Chem. 290: 20761-20773. PMID: 26134569

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1,6-Hexanediyl Bismethanethiosulfonate, 25 mg

sc-208808
25 mg
$330.00