HNRPLL Inhibitors
Chemical inhibitors of HNRPLL function through various mechanisms, primarily by targeting the phosphorylation process that is essential for the protein's activity in RNA processing. Phorbol 12-myristate 13-acetate (PMA), a diacylglycerol analog, initially activates protein kinase C (PKC), which in turn phosphorylates HNRPLL. However, chronic activation by PMA leads to PKC downregulation, which subsequently reduces HNRPLL phosphorylation and inhibits its function. Ro-31-8220 and Gö 6983 serve as PKC inhibitors, preventing PKC from phosphorylating HNRPLL, which is necessary for its role in alternative splicing of pre-mRNAs. Staurosporine, another broad-spectrum kinase inhibitor, prevents multiple kinases including PKC from phosphorylating HNRPLL, thereby inhibiting its function in RNA splicing. Calphostin C and Bisindolylmaleimide I are more selective PKC inhibitors, which block the phosphorylation of HNRPLL, with the same inhibitory outcome on its RNA processing activities.
Other inhibitors like Sotrastaurin, Enzastaurin, and Ruboxistaurin are selective towards PKC and its isoforms, leading to reduced phosphorylation of HNRPLL and consequent functional inhibition. Sotrastaurin particularly targets PKC to decrease HNRPLL activity, impacting its regulation of mRNA processing. Enzastaurin's inhibition of PKC beta, and Ruboxistaurin's selective inhibition of the PKC beta isoform, both result in diminished HNRPLL function due to reduced phosphorylation. Chelerythrine, a potent PKC inhibitor, blocks the kinase's activity, which is vital for HNRPLL phosphorylation and function. Lastly, Hispidin inhibits PKC, which is crucial for HNRPLL's role in the regulation of alternative splicing and other RNA processing functions, leading to a decrease in HNRPLL's functional capabilities.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol (DAG) analog which activates protein kinase C (PKC). Activation of PKC has been shown to phosphorylate HNRPLL and therefore can alter its function. Persistent activation by PMA can lead to PKC downregulation, which can result in reduced HNRPLL phosphorylation and thus functional inhibition of HNRPLL’s RNA processing activities. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a potent PKC inhibitor which can prevent the phosphorylation of substrates of PKC, including HNRPLL. Inhibition of PKC activity can therefore inhibit the function of HNRPLL by preventing its phosphorylation-dependent activities which are critical for its role in RNA splicing. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor that can inhibit various PKC isoforms. Given that PKC can phosphorylate HNRPLL, inhibition of PKC by Gö 6983 can lead to decreased phosphorylation and thus functional inhibition of HNRPLL's role in alternative splicing of pre-mRNAs. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that can inhibit several kinases including PKC. By inhibiting PKC, Staurosporine can prevent the phosphorylation and activation of HNRPLL, leading to its functional inhibition in the regulation of alternative splicing and other RNA processing events. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a specific inhibitor of PKC that inhibits the transfer of phosphate from ATP to substrate proteins, including HNRPLL. By inhibiting PKC-mediated phosphorylation, Calphostin C can functionally inhibit HNRPLL by preventing its activation and subsequent involvement in RNA splicing. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific PKC inhibitor that can inhibit the phosphorylation of PKC substrates, including HNRPLL. This inhibition can result in decreased activity of HNRPLL in its RNA processing functions. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin is a selective PKC inhibitor, which can inhibit the phosphorylation of PKC substrates such as HNRPLL. By inhibiting PKC, Sotrastaurin can decrease the functional activity of HNRPLL, inhibiting its role in the regulation of mRNA processing. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $259.00 $612.00 $1721.00 | 3 | |
Enzastaurin is a PKC beta inhibitor, which could decrease PKC-mediated phosphorylation of HNRPLL. This can lead to functional inhibition of HNRPLL, affecting its ability to regulate RNA splicing and other post-transcriptional modifications. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Ruboxistaurin is a selective inhibitor of PKC beta isoform. Given that HNRPLL function can be regulated by PKC-mediated phosphorylation, inhibition by Ruboxistaurin can lead to a decrease in HNRPLL phosphorylation, thus inhibiting its functional activity. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a potent, selective PKC inhibitor that can inhibit the phosphorylation of PKC substrates. By blocking PKC activity, Chelerythrine can inhibit the phosphorylation and thus the function of HNRPLL in RNA processing. | ||||||