HNRPLL Antibody (A-4): sc-390699
- HNRPLL Antibody (A-4) is a mouse monoclonal IgG1 κ HNRPLL antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 28-51 of HNRPLL of human origin
- HNRPLL Antibody (A-4) is recommended for detection of HNRPLL isoforms 1, 2, 3 and 4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-HNRPLL Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HNRPLL Antibody (A-4) for WB and IHC(P) applications. These reagents are now offered in bundles with HNRPLL Antibody (A-4) (see ordering information below).
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HNRPLL Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HNRPLL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HNRPLL antibody (A-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The heterogeneous nuclear ribonucleoprotein L-like (HNRPLL), also known as stromal RNA-regulating factor (SRRF), is a crucial 542 amino acid nuclear protein that plays a significant role in RNA processing. HNRPLL is primarily located in the nucleus, where HNRPLL is involved in the regulation of pre-mRNA splicing, a vital process for gene expression and cellular function. Nuclear localization allows HNRPLL to interact with pre-mRNA substrates and spliceosomal components, thereby influencing alternative splicing mechanisms that can affect protein diversity and function. HNRPLL shares 69% amino acid homology with hnRNP L, which also binds to the 3′ end of introns, further underscoring HNRPLL′s role in mRNA processing. HNRPLL contains three RNA-regulating motif (RRF) domains that feature RNA-binding regions, facilitating interaction with RNA molecules. HNRPLL interacts with BAT1, an RNA-dependent ATPase that regulates ATP hydrolysis during pre-mRNA splicing, highlighting HNRPLL′s importance in the splicing machinery. HNRPLL is widely expressed across various human tissues, including the pancreas, lung, kidney, placenta, heart, skeletal muscle, and bone marrow stromal cells, and is produced as four isoforms through alternative splicing, reflecting HNRPLL′s diverse functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HNRPLL Antibody (A-4) References:
- Novel functional role of CA repeats and hnRNP L in RNA stability. | Hui, J., et al. 2003. RNA. 9: 931-6. PMID: 12869704
- Alternatively spliced isoforms of a novel stromal RNA regulating factor. | Shur, I., et al. 2004. Gene. 334: 113-21. PMID: 15256261
- Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. | Hui, J., et al. 2005. EMBO J. 24: 1988-98. PMID: 15889141
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | Lim, J., et al. 2006. Cell. 125: 801-14. PMID: 16713569
- Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. | Hung, LH., et al. 2008. RNA. 14: 284-96. PMID: 18073345
- Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with heterogeneous nuclear ribonucleoprotein L. | Park, HG., et al. 2007. J Biosci. 32: 1263-72. PMID: 18202450
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNRPLL Antibody (A-4) | sc-390699 | 200 µg/ml | $322.00 | |||
HNRPLL Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-530232 | 200 µg Ab; 10 µg BP | $361.00 | |||
HNRPLL Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-523643 | 200 µg Ab, 40 µg BP | $361.00 | |||
HNRPLL Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-543942 | 200 µg Ab; 20 µg BP | $361.00 | |||
HNRPLL Antibody (A-4) AC | sc-390699 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HNRPLL Antibody (A-4) HRP | sc-390699 HRP | 200 µg/ml | $322.00 | |||
HNRPLL Antibody (A-4) FITC | sc-390699 FITC | 200 µg/ml | $336.00 | |||
HNRPLL Antibody (A-4) PE | sc-390699 PE | 200 µg/ml | $349.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 488 | sc-390699 AF488 | 200 µg/ml | $364.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 546 | sc-390699 AF546 | 200 µg/ml | $364.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 594 | sc-390699 AF594 | 200 µg/ml | $364.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 647 | sc-390699 AF647 | 200 µg/ml | $364.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 680 | sc-390699 AF680 | 200 µg/ml | $364.00 | |||
HNRPLL Antibody (A-4) Alexa Fluor® 790 | sc-390699 AF790 | 200 µg/ml | $364.00 | |||
HNRPLL (A-4) Neutralizing Peptide | sc-390699 P | 100 µg/0.5 ml | $69.00 |