HNK-1ST Activators
HNK-1ST Activators are a diverse group of compounds that indirectly promote the functional activity of HNK-1ST through various signaling pathways. The activation of adenylate cyclase by compounds like Forskolin and Sodium Fluoride results in increased cAMP levels, which in turn activate PKA. This kinase is crucial for phosphorylating proteins within the HNK-1ST pathway, which can enhance the protein's activity by increasing its enzymatic efficiency or substrate affinity. Compounds such as IBMX and Rolipram prevent the degradation of cAMP, while Anandamide indirectly increases cAMP levels through its interaction with cannabinoid receptors, all leading to a similar enhancement of HNK-1ST via PKA activation.
Similarly, neurotransmitters such as glutamate, GABA, acetylcholine, dopamine, serotonin, histamine, and glycine initiate distinct signaling pathways that can modify the phosphorylation state of proteins within the HNK-1ST signaling network. The activation of these signaling pathways by neurotransmitter-receptor interaction can lead to calcium influx or activation of kinases such as PKC, which in turn may enhance the functional activity of HNK-1ST through phosphorylation of associated proteins. L-Glutamine serves as a precursor for neurotransmitters that are involved in HNK-1ST-related pathways, providing an indirect means to enhance HNK-1ST activity. Adenosine acts through a feedback mechanism that can result in upregulation of cAMP/PKA signaling, thereby influencing HNK-1ST activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine interacts with adrenergic receptors, which can stimulate the cAMP/PKA pathway. PKA phosphorylation can enhance the activity of HNK-1ST by facilitating its substrate recognition or enzymatic turnover rate. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine binds to adrenergic receptors leading to the activation of the cAMP/PKA signaling pathway. This can indirectly enhance the functional activity of HNK-1ST by increasing phosphorylation of substrates within its pathway. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $291.00 $566.00 | ||
Glutamate acts on its receptors leading to calcium influx and activation of calcium/calmodulin-dependent protein kinases, which can phosphorylate proteins that interact with HNK-1ST, enhancing its functional activity. | ||||||
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $63.00 $133.00 $450.00 $750.00 | 2 | |
GABA interaction with GABA_A receptors causes an influx of chloride ions, which can modulate neuronal excitability. This may alter the phosphorylation state of proteins in pathways where HNK-1ST is active, leading to its functional enhancement. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to its receptors and can activate cAMP/PKA signaling. PKA can phosphorylate proteins that are part of the HNK-1ST pathway, potentially enhancing the enzymatic activity of HNK-1ST. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $520.00 | 3 | |
Serotonin can act through its receptors to activate PLC, which catalyzes the production of IP3 and DAG, leading to calcium release and PKC activation. PKC may phosphorylate proteins that enhance HNK-1ST activity. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its H1 receptors, activates PLC, resulting in PKC activation. Activated PKC can phosphorylate proteins within the HNK-1ST signaling pathway, thereby enhancing its functional activity. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine functions as an inhibitory neurotransmitter and can modulate cellular signaling cascades. This modulation can influence the phosphorylation of proteins that interact with or regulate HNK-1ST, enhancing its activity. | ||||||
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $36.00 $46.00 $97.00 $372.00 $719.00 | 2 | |
L-Glutamine is a precursor for the synthesis of glutamate and GABA, which are neurotransmitters that can influence signaling pathways involving HNK-1ST. This can lead to an indirect enhancement of HNK-1ST activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine interacts with its receptors, which can inhibit adenylate cyclase activity, leading to a compensatory upregulation of cAMP/PKA signaling. This upregulation can enhance the function of HNK-1ST. | ||||||