HLA-A2 Inhibitors
HLA-A2 inhibitors are a class of chemical compounds that specifically target and interact with the human leukocyte antigen A2 (HLA-A2) protein. HLA-A2 is a major histocompatibility complex (MHC) class I molecule found on the surface of most nucleated cells in the human body. It plays a crucial role in the immune system by presenting antigens to cytotoxic T cells, thereby initiating immune responses against infected or abnormal cells. HLA-A2 inhibitors are designed to inhibit the function of this MHC class I molecule, primarily for research purposes. By binding to HLA-A2, these inhibitors can alter the presentation of antigens to T cells, influencing the immune response.
The development and study of HLA-A2 inhibitors are of great interest to immunologists and researchers in the field of immunology. These compounds allow scientists to investigate the intricacies of antigen presentation and T cell recognition, shedding light on fundamental aspects of the immune system's function. Understanding how HLA-A2 inhibitors interact with the HLA-A2 molecule and influence antigen presentation can provide valuable insights into immune responses and autoimmune diseases
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor that can lead to hypomethylation of DNA and affect the expression of various genes, potentially including HLA-A2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate several signaling pathways and could potentially downregulate the expression of MHC class I molecules, including HLA-A2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This green tea polyphenol has been reported to have various regulatory effects on cellular processes that could affect HLA-A2 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
As an Nrf2 activator, DL-Sulforaphane might influence the oxidative stress response pathway, which could modulate HLA-A2 expression indirectly. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine can impact endosomal pH and potentially alter the processing and presentation of antigens by MHC class I molecules. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate impacts folate metabolism and has been shown to affect the proliferation of cells and the expression of certain genes, which may include those related to HLA-A2. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic(III) oxide can lead to cellular stress and affect signaling pathways, which may result in altered HLA-A2 expression. | ||||||