HJURP Activators
The chemical class known as HJURP Activators encompasses a group of compounds that, while not directly interacting with HJURP, may modulate cellular pathways or chromatin states that indirectly affect the function of HJURP. These chemicals can influence chromatin remodeling, DNA repair, histone modification, and gene expression, thereby potentially creating an intracellular environment conducive to HJURP's role in centromere assembly and CENP-A incorporation. Although these activators are not known to bind directly to HJURP, their actions on other molecular targets can result in an increase in the efficiency or availability of HJURP for its essential role during cell division.
The mechanisms by which these chemicals may activate HJURP are diverse. For example, flavonoids like quercetin might modulate kinase signaling pathways, influencing DNA repair and chromatin remodeling processes. Phenolic compounds such as resveratrol can activate sirtuin proteins affecting histone modifications, while inhibitors of histone deacetylase, like Trichostatin A and Sodium Butyrate, alter the chromatin landscape, potentially enhancing HJURP's ability to bind to centromeric DNA. In addition, nucleoside analogs like 5-Azacytidine modify the methylation patterns of DNA, potentially affecting gene expression systems that intersect with HJURP's activity. Each of these compounds, through their unique actions on various biochemical pathways, represents a potential indirect approach to modulating the activity of HJURP.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid commonly found in fruits and vegetables. It has been shown to modulate kinase activity and influence chromatin remodeling and DNA repair processes. By affecting these pathways, quercetin may indirectly increase the incorporation of CENP-A at centromeres, a process facilitated by HJURP, thus potentially upregulating its activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural phenol found in red grapes and berries. By activating SIRT1, a NAD-dependent deacetylase, resveratrol influences histone modification and may affect the availability of centromeric DNA for HJURP binding. This can potentially enhance the efficiency of HJURP in chromatin assembly during the cell cycle. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It is known to affect chromatin structure and function, thus potentially influencing the recruitment of HJURP to centromeric regions by creating a more accessible chromatin state. This could indirectly facilitate the function of HJURP in centromere assembly and maintenance. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that incorporates into DNA and RNA, causing demethylation of DNA. The demethylation can influence gene expression patterns, potentially affecting the expression of proteins involved in centromere function, and indirectly affect the functional activity of HJURP by altering the cellular environment in which it operates. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that acts as a histone deacetylase inhibitor. Its action can lead to a relaxed chromatin state, potentially facilitating the binding of HJURP to centromeric DNA by enhancing the accessibility of the chromatin. This could result in an increased activity of HJURP in the assembly of nucleosomes containing CENP-A at centromeres. | ||||||