hIws1 Inhibitors
Chemical inhibitors of hIws1 can achieve functional inhibition through various molecular interactions that disrupt the protein's role in transcriptional regulation and mRNA processing. Trichostatin A and Vorinostat (Suberoylanilide Hydroxamic Acid), both histone deacetylase inhibitors, increase histone acetylation, which can counteract the chromatin remodeling contributions of hIws1, thus impeding its role in transcriptional elongation. Similarly, EPZ-6438 and GSK126, as EZH2 methyltransferase inhibitors, prevent methylation of histone H3, a post-translational modification that hIws1 relies on to exert its function in gene expression regulation. The result is a disruption of the chromatin states that are conducive for hIws1's operation within the transcriptional framework. Additionally, MS-275's inhibition of histone deacetylation also alters acetylation patterns, which can obstruct hIws1's interaction with the modified histones, effectively inhibiting its function.
Furthermore, Cyclopamine's inhibition of the Hedgehog signaling pathway can suppress the transcription of genes that code for proteins vital to hIws1's mRNA processing role, thereby diminishing its functional activity. PF-477736, a checkpoint kinase inhibitor, may interfere with cell cycle progression and DNA damage response, both of which are processes that hIws1 is thought to be involved in, leading to a decrease in hIws1 activity. Ibrutinib's action on Bruton's tyrosine kinase can disrupt B-cell receptor signaling, which may reduce the expression of transcriptional coactivators essential for hIws1's function. In the realm of epigenetic modification, A-366's inhibition of G9a/GLP methyltransferase could similarly hinder the methylation of histone H3, impacting hIws1's regulation of transcription. UNC1999's dual inhibition of EZH2 and EZH1 may lead to an alteration in histone methylation patterns and affect the chromatin remodeling and transcriptional programs involving hIws1. JQ1 disrupts the recognition of acetylated histones by transcriptional regulators, which is a critical step for hIws1 in the process of chromatin remodeling and transcriptional elongation. Lastly, YK-4-279 disrupts the EWS-FLI1 interaction, which is relevant to transcriptional regulation and mRNA splicing processes involving hIws1, thereby inhibiting its function in these cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which would increase the acetylation of histones, counteracting the chromatin remodeling function that hIws1 is associated with, leading to a functional inhibition of hIws1's role in transcriptional elongation and histone modification. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway, which could suppress the transcription of genes whose products are necessary for hIws1's function in mRNA processing, thus leading to a functional inhibition of hIws1. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $113.00 $423.00 | ||
PF-477736 is a checkpoint kinase inhibitor which could interfere with cell cycle progression and DNA damage response, pathways that hIws1 may function within, possibly inhibiting hIws1's role in the transcriptional responses to these cellular events. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $90.00 $238.00 $300.00 | ||
GSK126 is an EZH2 methyltransferase inhibitor, which would prevent methylation of histone H3, a modification that can be necessary for the proper function of hIws1 in transcriptional regulation, resulting in its functional inhibition. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is another EZH2 inhibitor, which could disrupt the polycomb repressive complex 2 (PRC2) function leading to altered chromatin states that would be unsuitable for hIws1's role in transcriptional elongation and mRNA splicing, functionally inhibiting it. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib is a Bruton's tyrosine kinase inhibitor that could disrupt B-cell receptor signaling, potentially reducing the expression of transcriptional coactivators necessary for hIws1's function, leading to its functional inhibition. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor increasing acetylation levels of histones, potentially obstructing the chromatin context necessary for hIws1's role in transcriptional elongation, resulting in functional inhibition. | ||||||
A-366 | 1527503-11-2 | sc-507495 | 10 mg | $195.00 | ||
A-366 is a selective G9a/GLP methyltransferase inhibitor that could prevent the methylation of histone H3, which may be required for hIws1's function, leading to functional inhibition of hIws1's activities in transcriptional regulation. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is an inhibitor of EZH2 and EZH1, which could alter histone methylation patterns, affecting chromatin states and the transcriptional programs where hIws1 is involved, resulting in functional inhibition of hIws1. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a histone deacetylase inhibitor that could alter the acetylation of histones, affecting the transcriptional regulation and chromatin remodeling activities where hIws1 functions, resulting in its functional inhibition. | ||||||