HIV gp24 Inhibitors
HIV gp24 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the HIV gp24 protein, also known as p24 antigen or capsid protein. Gp24 is a structural protein found in the human immunodeficiency virus (HIV), specifically in the mature viral particle. It plays a critical role in the viral life cycle by forming the outer shell of the viral core, which encases the viral genetic material, RNA. This protein is essential for the assembly and structural integrity of the virus, as it contributes to the formation of the mature, infectious virion. Inhibitors developed to target HIV gp24 are primarily employed in research settings to investigate the functional properties and structural aspects associated with this protein.
The development of HIV gp24 inhibitors often involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with gp24 and modulate its functions. By inhibiting gp24, these compounds can potentially disrupt the assembly and structural integrity of the viral core, leading to the production of non-infectious viral particles. Researchers use gp24 inhibitors to explore the intricate roles played by this protein in the HIV life cycle, attempting to unravel its contributions to viral assembly, maturation, and infectivity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
A nucleoside analog that inhibits HIV reverse transcriptase, potentially reducing p24 protein synthesis. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $168.00 | 3 | |
A non-nucleoside reverse transcriptase inhibitor that can prevent the conversion of viral RNA to DNA, indirectly reducing p24 levels. | ||||||
Nevirapine | 129618-40-2 | sc-208092 | 5 mg | $97.00 | 5 | |
Another non-nucleoside reverse transcriptase inhibitor that may lead to decreased synthesis of viral DNA and p24. | ||||||
Lopinavir | 192725-17-0 | sc-207831 | 10 mg | $129.00 | 6 | |
An HIV protease inhibitor which could prevent the cleavage of gag-pol polyproteins, thus inhibiting p24 production. | ||||||
Ritonavir | 155213-67-5 | sc-208310 | 10 mg | $122.00 | 7 | |
Often used in combination with other protease inhibitors to enhance their effects, potentially reducing p24 levels. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
A protease inhibitor that could inhibit the cleavage of viral polyprotein precursors, affecting p24 production. | ||||||
Raltegravir | 518048-05-0 | sc-364600 sc-364600A sc-364600B sc-364600C sc-364600D | 5 mg 50 mg 100 mg 500 mg 1 g | $100.00 $821.00 $1229.00 $2861.00 $4085.00 | 21 | |
An integrase inhibitor that prevents the integration of viral DNA into the host genome, potentially reducing p24 expression. | ||||||
Tenofovir | 147127-20-6 | sc-204335 sc-204335A | 10 mg 50 mg | $154.00 $633.00 | 11 | |
A nucleotide reverse transcriptase inhibitor that can decrease the synthesis of viral DNA, indirectly reducing p24. | ||||||