Lopinavir CAS: 192725-17-0
MF: C37H48N4O5
MW: 628.80
An HIV-1 protease inhibitor.

Lopinavir (CAS 192725-17-0)

Lopinavir | CAS 192725-17-0 is rated 5.0 out of 5 by 1.
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Alternate Names: ABT-378
Application: Lopinavir is an HIV-1 protease inhibitor
CAS Number: 192725-17-0
Purity: ≥99%
Molecular Weight: 628.80
Molecular Formula: C37H48N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Lopinavir is an antiretroviral of the protease inhibitor class. Inhibition of HIV-1 protease prevents cleavage of the viral polyprotein precursor and results in the release of immature, noninfectious virions. A component of combination therapy to treat HIV/AIDS.


References

Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMF (~14 mg/ml), methanol, DMSO (126 mg/ml at 25° C), water (< 1 mg/ml at 25° C), and ethanol (126 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
124-127° C
Boiling Point :
~924.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Human immunodeficiency virus 1: IC50 = 1 nM; Human immunodeficiency virus 2: IC50 = 4 nM; MT4: IC50 = 35 nM (human); Human immunodeficiency virus: IC50 = 40 nM; Mdr-1: IC50 = 1.7 µM (human)
Ki Data :
Human immunodeficiency virus type 1 protease: Ki= 1.3 pM (Human immunodeficiency virus 1); CYP3A4: Ki= 410 nM (human); mutant HIV protease V82T: Ki= 3.6 pM; mutant HIV protease V82F: Ki= 3.7 pM; mutant HIV protease V82A: Ki= 4.9 pM
pK Values :
pKa: 13.89 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UV6264135
PubChem CID :
92727
MDL Number :
MFCD22373646
SMILES :
CC1=C(C(=CC=C1)C)OCC(=O)N[[email protected]@H](CC2=CC=CC=C2)[[email protected]](C[[email protected]](CC3=CC=CC=C3)NC(=O)[[email protected]](C(C)C)N4CCCNC4=O)O

Download SDS (MSDS)

Certificate of Analysis

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Lopinavir (CAS 192725-17-0)  Product Citations

See how others have used Lopinavir (CAS 192725-17-0). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31133852  Bresciani, E. et al. 2019. Front Pharmacol. 10: 461.

PMID: # 26824902  Hampson, L. et al. 2016. PLoS ONE. 11: e0147917.

PMID: # 25988960  Zhu, Q. et al. 2015. Sci Rep. 5: 10323.

PMID: # 21068005  Leroyer, S. et al. 2011. J. Lipid Res. 52: 207-20.

PMID: # 20884875  Lefèvre C et al. 2010. Arterioscler Thromb Vasc Biol. 30: 2611-2620.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Duan et al Duan et al. (PubMed ID 26285765) used Lopinavir to selectively inhibit the plasma membrane monoamine transporter (PMAT). -SCBT Publication Review
Date published: 2015-06-25
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