Molecular structure of Lopinavir, CAS Number: 192725-17-0
Lopinavir (CAS 192725-17-0)
See product citations (6)
Alternate Names:
ABT-378
Application:
Lopinavir is an HIV-1 protease inhibitor
CAS Number:
192725-17-0
Purity:
≥99%
Molecular Weight:
628.80
Molecular Formula:
C37H48N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lopinavir is a protease inhibitor that functions by binding to the active site of the HIV-1 protease enzyme. This binding prevents the cleavage of viral Gag-Pol polyproteins, ultimately inhibiting the maturation of infectious HIV particles. By interfering with the proteolytic processing of viral polyproteins, lopinavir disrupts the production of mature viral particles. Through its interaction with the active site of the protease enzyme, lopinavir effectively disrupts the viral replication cycle.
Lopinavir (CAS 192725-17-0) References
- The lopinavir/ritonavir-associated rise in lipids is not related to lopinavir or ritonavir plasma concentration. | Bierman, WF., et al. 2011. Antivir Ther. 16: 647-55. PMID: 21817186
- CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir. | Li, F., et al. 2012. Drug Metab Dispos. 40: 18-24. PMID: 21953914
- Combination lopinavir and ritonavir alter exogenous and endogenous bile acid disposition in sandwich-cultured rat hepatocytes. | Griffin, LM., et al. 2013. Drug Metab Dispos. 41: 188-96. PMID: 23091188
- Enhanced Eryptosis Following Exposure to Lopinavir. | Bissinger, R., et al. 2015. Cell Physiol Biochem. 37: 2486-95. PMID: 26681533
- Lopinavir/ritonavir enhanced the antimalarial activity of amodiaquine and artesunate in a mouse model of Plasmodium berghei. | Abiodun, OO., et al. 2016. J Chemother. 28: 482-486. PMID: 26900802
- Improvement of lipoatrophy by switching from efavirenz to lopinavir/ritonavir. | Rojas, J., et al. 2016. HIV Med. 17: 340-9. PMID: 27089862
- Lopinavir/Ritonavir Treatment Induces Oxidative Stress and Caspaseindependent Apoptosis in Human Glioblastoma U-87 MG Cell Line. | Gratton, R., et al. 2018. Curr HIV Res. 16: 106-112. PMID: 29804534
- Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells. | Okubo, K., et al. 2019. Anticancer Res. 39: 5891-5901. PMID: 31704813
- 3D-printing of lopinavir printlets by selective laser sintering and quantification of crystalline fraction by XRPD-chemometric models. | Hamed, R., et al. 2021. Int J Pharm. 592: 120059. PMID: 33171261
- Lopinavir/ritonavir, a new galenic oral formulation from commercial solid form, fine-tuned by nuclear magnetic resonance spectroscopy. | Desideri, I., et al. 2022. Eur J Hosp Pharm. 29: 259-263. PMID: 33214132
- Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats. | Hu, Y., et al. 2021. J Zhejiang Univ Sci B. 22: 599-602. PMID: 34269012
- Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1. | Heaton, BJ., et al. 2022. Biomed Pharmacother. 150: 112999. PMID: 35461087
- Menthol augmented niosomes for enhanced intestinal absorption of lopinavir. | Fayed, ND., et al. 2022. Pharm Dev Technol. 27: 956-964. PMID: 36227222
- Evaluation of the polymorphic forms of ritonavir and lopinavir in raw materials and co-milled systems. | Moreira Pinheiro, LB., et al. 2022. Int J Pharm. 628: 122329. PMID: 36280220
Inhibitor of:
Alphavirus, ATP-binding cassette (ABC) transporter, BSEP, CDV, CHCHD2, CMTM7, Coronavirus, FDC-SP, FIV gp36, Fv1, G1P3, Hep A, HHV-8 B, HIV gp24, HIV-1 p17, HIV-1 p55, HIV-1 Protease, HPV 16-E5, HPV16 E6, HPV18 E2, HTLV-1 p19, KIAA1305, LSm10, NANP, PCSK1N, Protease, PRX I, PXR, S3-12, Signal peptidase I, SR-2C, ST18, TRIM5, UGT1A2, UGT1A6A, and V1RC19.Activator of:
FIV p24, FIV Vif, and HIV-1 Nef.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lopinavir, 10 mg | sc-207831 | 10 mg | $129.00 |