HIV-1 Tat Activators
HIV-1 Tat activators comprise a specialized class of chemical compounds that have been a focal point of research within the field of virology and molecular biology. These molecules are recognized for their unique ability to modulate the activity of the HIV-1 Tat protein. Tat (Trans-Activator of Transcription) is a viral regulatory protein produced by the human immunodeficiency virus type 1 (HIV-1), which plays a pivotal role in the transcription and replication of the viral genome. Tat activators primarily function by interacting with the Tat protein, influencing its structural conformation or enhancing its transcriptional activity.
The central role of HIV-1 Tat in the HIV life cycle makes Tat activators essential tools for studying the virus's replication mechanisms and the intricate interplay between viral and host cellular factors. By manipulating Tat activity, researchers can delve deeper into the molecular processes that govern HIV-1 transcription and replication, shedding light on the virus's ability to evade host defenses and establish chronic infections. Tat activators significance lies in their contribution to our understanding of HIV-1 pathogenesis and the development of strategies for combating the virus. These compounds serve as valuable tools for elucidating the complex interactions that underlie HIV infection and may hold promise for future research endeavors in virology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $138.00 $530.00 | 24 | |
Prostratin is a non-tumor promoting phorbol ester that activates Protein Kinase C (PKC). It indirectly activates HIV-1 Tat by promoting the transcriptional activity of the long terminal repeat (LTR) of HIV-1. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is another PKC activator that enhances HIV-1 LTR-mediated transcription, thereby indirectly increasing Tat activity. | ||||||
Ingenol 3-angelate | 75567-37-2 | sc-364214 sc-364214A | 1 mg 5 mg | $189.00 $734.00 | 3 | |
This is a diterpene ester known to activate PKC, leading to increased HIV LTR transcription and subsequent Tat activation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that indirectly influences HIV-1 Tat by modifying chromatin structure and enhancing LTR-driven transcription. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can reactivate latent HIV-1 by modulating Tat expression, although its precise mechanism related to Tat is not fully elucidated. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor that can increase HIV-1 expression by enhancing the acetylation of histones, indirectly affecting Tat activity. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Similar to Vorinostat, Panobinostat is a histone deacetylase inhibitor that increases HIV-1 gene expression, potentially affecting Tat. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
This is another histone deacetylase inhibitor that can activate HIV-1 transcription and thereby influence Tat activity. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a histone methyltransferase inhibitor that could indirectly activate HIV-1 Tat by altering chromatin structure and promoting LTR transcription. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $90.00 $238.00 $300.00 | ||
GSK126 is a potent EZH2 methyltransferase inhibitor that might impact Tat activity by modifying the epigenetic landscape of HIV-1 infected cells. | ||||||