HIV-1 Tat Antibody (02-001): sc-65912

HIV-1 Tat Antibody (02-001) is a mouse monoclonal IgG2b antibody that detects HIV-1 Tat protein by western blotting (WB) and immunoprecipitation (IP). Anti-HIV-1 Tat antibody (02-001) is available as a non-conjugated format, specifically designed to facilitate research into HIV pathogenesis mechanisms. HIV-1 Tat protein, also known as Tbp1, is a pivotal viral protein that plays a crucial role in transcriptional activation of HIV genes, significantly influencing viral replication cycles. Anti-HIV-1 Tat antibody (02-001) helps researchers study how HIV-1 Tat enhances viral gene expression, which is essential for virus persistence within hosts and contributes to chronic immune activation in HIV-infected individuals. HIV-1 Tat protein interacts with various cellular proteins, including transcription factors and co-activators, modulating host cell functions. Anti-HIV-1 Tat antibody (02-001) enables investigation of neurotoxic properties and proinflammatory responses in microglia, highlighting HIV-1 Tat′s involvement in AIDS development and associated neurological complications. Using HIV-1 Tat monoclonal antibody (02-001) in research provides valuable insights into complex interactions between HIV-1 and host immune systems, paving the way for potential therapeutic strategies.

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HIV-1 Tat Antibody (02-001) References:

1. HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions.  |  Hu, XT. 2016. Curr Drug Targets. 17: 4-14. PMID: 26028040
2. Recent Advances in Targeting the HIV-1 Tat/TAR Complex.  |  Abulwerdi, FA. and Le Grice, SFJ. 2017. Curr Pharm Des. 23: 4112-4121. PMID: 28625133
3. Genetic variation and function of the HIV-1 Tat protein.  |  Spector, C., et al. 2019. Med Microbiol Immunol. 208: 131-169. PMID: 30834965
4. Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND.  |  Marino, J., et al. 2020. Cell Mol Life Sci. 77: 5079-5099. PMID: 32577796
5. Neurotoxicity of HIV-1 Tat is attributed to its penetrating property.  |  Tang, X., et al. 2020. Sci Rep. 10: 14002. PMID: 32814783
6. 17⍺-Estradiol Protects against HIV-1 Tat-Induced Endolysosome Dysfunction and Dendritic Impairments in Neurons.  |  Datta, G., et al. 2023. Cells. 12: PMID: 36899948
7. HIV-1 Tat-mediated microglial ferroptosis involves the miR-204-ACSL4 signaling axis.  |  Kannan, M., et al. 2023. Redox Biol. 62: 102689. PMID: 37023693
8. NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.  |  Lin, S., et al. 2023. Neurotox Res. 41: 398-407. PMID: 37060393
9. HIV-1 Tat Upregulates TREM1 Expression in Human Microglia.  |  Campbell, GR., et al. 2023. J Immunol. 211: 429-442. PMID: 37326481
10. Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk.  |  Li, Y., et al. 2024. Sci Adv. 10: eadi4162. PMID: 38241362

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HIV-1 Tat Antibody (02-001) has 8 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HIV-1 Tat Antibody (02-001) Specifications

Alternate Product Name: HIV-1 Tat

Product Clone Name: 02-001

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 2-9

Epitope Target: Tat

Epitope Species: HIV-1

Product Reactivity/Detection: Tat

Species Reactivity/Detection: HIV-1

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for HIV-1 Tat Antibody (02-001): N/A

The preferred HIV-1 Tat antibody is HIV-1 Tat Antibody (02-010): sc-65915.