Histone Modification
Items 21 to 30 of 101 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PCI-34051 | 950762-95-5 | sc-364566 sc-364566A | 10 mg 100 mg | $189.00 $1671.00 | 5 | |
PCI-34051 is a selective inhibitor of the histone demethylase KDM5, which plays a crucial role in the regulation of histone methylation. By binding to the active site of KDM5, PCI-34051 disrupts the demethylation process, resulting in the accumulation of methylated histones. This alteration in histone marks can lead to significant changes in chromatin accessibility and gene transcription, thereby influencing various cellular pathways and epigenetic landscapes. | ||||||
AMI-1, sodium salt | 20324-87-2 | sc-205928 sc-205928A | 5 mg 25 mg | $114.00 $398.00 | 2 | |
AMI-1, sodium salt, acts as a potent modulator of histone acetylation, specifically targeting histone acetyltransferases. By competitively inhibiting these enzymes, AMI-1 alters the acetylation status of histones, leading to a reconfiguration of chromatin structure. This modification enhances or represses gene expression through distinct pathways, influencing transcriptional dynamics and cellular responses. Its unique interaction with histone proteins underscores its role in epigenetic regulation. | ||||||
Curcumin (Synthetic) | 458-37-7 | sc-294110 sc-294110A | 5 g 25 g | $52.00 $156.00 | 3 | |
Curcumin (Synthetic) serves as a significant agent in histone modification by influencing histone methylation processes. It interacts with specific methyltransferases, altering their activity and subsequently modifying the chromatin landscape. This modulation can lead to changes in gene accessibility and transcriptional regulation. The compound's ability to affect the balance of histone marks highlights its role in epigenetic mechanisms, impacting cellular identity and function. | ||||||
4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide | 193551-00-7 | sc-223859 sc-223859A sc-223859B sc-223859C sc-223859D | 1 mg 5 mg 10 mg 25 mg 60 mg | $39.00 $155.00 $272.00 $588.00 $1254.00 | 5 | |
4-(Dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide acts as a potent modulator of histone methylation, engaging in specific hydrogen bonding interactions with histone methyltransferases. Its unique molecular configuration enhances substrate affinity, promoting the transfer of methyl groups to lysine residues on histones. This modification leads to altered chromatin structure, influencing gene expression patterns and cellular differentiation processes. The compound's ability to stabilize enzyme-substrate complexes further enhances its efficacy in histone modification pathways. | ||||||
Tubacin | 537049-40-4 | sc-362815 sc-362815A sc-362815B sc-362815C sc-362815D | 1 mg 5 mg 50 mg 500 mg 1 g | $201.00 $438.00 $4334.00 $10754.00 $13947.00 | 8 | |
Tubacin is a potent inhibitor of histone deacetylases (HDACs), specifically targeting HDAC6, which leads to increased acetylation of histones and non-histone proteins. This alteration enhances the recruitment of transcriptional co-activators and promotes a more relaxed chromatin structure. By disrupting the deacetylation process, Tubacin influences cellular signaling pathways and protein stability, thereby playing a crucial role in the regulation of gene expression and cellular responses. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $110.00 $343.00 | 9 | |
Apicidin is a selective inhibitor of histone deacetylases (HDACs), particularly affecting HDAC1 and HDAC2. Its unique structure allows it to form specific interactions with the active site of these enzymes, leading to a significant increase in histone acetylation. This modification alters chromatin dynamics, facilitating transcriptional activation. Additionally, Apicidin can modulate various signaling pathways by influencing the acetylation status of non-histone proteins, thereby impacting cellular functions. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
Scriptaid is a selective inhibitor of histone deacetylases (HDACs), characterized by its ability to disrupt the interaction between HDACs and histone proteins. By forming specific non-covalent interactions, it promotes the acetylation of histones, leading to a more relaxed chromatin structure. This alteration facilitates transcriptional activation and enhances the accessibility of DNA to transcription factors, thereby influencing epigenetic regulation and cellular processes. Its unique binding dynamics contribute to its role in modulating histone acetylation levels. | ||||||
Quercetin Dihydrate | 6151-25-3 | sc-203225 sc-203225A | 5 g 25 g | $36.00 $61.00 | 1 | |
Quercetin Dihydrate exhibits a unique capacity to influence histone modification through its interaction with chromatin remodeling complexes. By stabilizing the acetylated form of histones, it enhances the recruitment of transcriptional co-activators. This compound also engages in specific hydrogen bonding and π-π stacking interactions, which can alter the conformational dynamics of histones, thereby impacting gene expression patterns and chromatin accessibility. Its multifaceted role in epigenetic modulation underscores its significance in cellular regulation. | ||||||
Eosin Y Disodium Trihydrate | 17372-87-1 | sc-202776 sc-202776A sc-202776B sc-202776C sc-202776D | 50 mg 500 mg 5 g 50 g 100 g | $119.00 $156.00 $198.00 $396.00 $676.00 | 1 | |
Eosin Y Disodium Trihydrate plays a pivotal role in histone modification by acting as a potent dye that can intercalate into nucleic acids, influencing chromatin structure. Its unique ability to form electrostatic interactions with positively charged histone tails facilitates the alteration of histone conformation. This compound can also modulate the activity of histone-modifying enzymes, thereby impacting the dynamics of gene expression and chromatin organization through distinct pathways. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 is a small molecule that influences histone modification by selectively inhibiting specific deacetylases, leading to an accumulation of acetylated histones. This alteration in histone acetylation status can disrupt the interaction between histones and DNA, promoting a more relaxed chromatin structure. Additionally, Tenovin-6 engages in unique molecular interactions that can modulate transcriptional activity, thereby affecting cellular processes through distinct regulatory pathways. | ||||||