Molecular structure of PCI-34051, CAS Number: 950762-95-5
PCI-34051 (CAS 950762-95-5)
See product citations (5)
Alternate Names:
1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide
Application:
PCI-34051 is a potent and specific HDAC8 inhibitor
CAS Number:
950762-95-5
Molecular Weight:
296.32
Molecular Formula:
C17H16N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PCI-34051 is a potent and specific HDAC8 (histone deacetylase 8) inhibitor (IC50 = 10 nM). PCI-34051 reveals greater than 200-fold selectivity over HDAC1 and HDAC6, and greater than 1000-fold selectivity over HDAC2, HDAC3 and HDAC10. PCI-34051, a novel small molecule, belongs to the indole family of compounds as a derivative of indole-6-carboxamide. Notably, it exhibits a diverse array of biological activities. Its inhibitory effects encompass the growth of specific cancer cell lines, fungi, and the release of pro-inflammatory cytokines. Such multifaceted properties make PCI-34051 a compelling candidate for further exploration and potential applications in various fields of research.
PCI-34051 (CAS 950762-95-5) References
- A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. | Balasubramanian, S., et al. 2008. Leukemia. 22: 1026-34. PMID: 18256683
- Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition. | Sleiman, SF., et al. 2014. J Neurosci. 34: 14328-37. PMID: 25339746
- Therapeutic effects of histone deacetylase inhibitors in a murine asthma model. | Ren, Y., et al. 2016. Inflamm Res. 65: 995-1008. PMID: 27565183
- Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. | Morgen, M., et al. 2020. ChemMedChem. 15: 1163-1174. PMID: 32348628
- Histone-deacetylase 8 drives the immune response and the growth of glioma. | Mormino, A., et al. 2021. Glia. 69: 2682-2698. PMID: 34310727
- HDAC8 drives spindle organization during meiotic maturation of porcine oocytes. | Chen, Y., et al. 2021. Cell Prolif. 54: e13119. PMID: 34435400
- An HDAC8-selective fluorescent probe for imaging in living tumor cell lines and tissue slices. | Yan, Y., et al. 2021. Org Biomol Chem. 19: 8352-8366. PMID: 34528053
- Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis. | Schmidt, O., et al. 2021. J Exp Clin Cancer Res. 40: 322. PMID: 34654445
- HDAC8-inhibitor PCI-34051-induced exosomes inhibit human bronchial smooth muscle cell proliferation via miR-381-3p mediated TGFB3. | Bai, SY., et al. 2021. Pulm Pharmacol Ther. 71: 102096. PMID: 34740750
- Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury. | Long, K., et al. 2022. ACS Pharmacol Transl Sci. 5: 207-215. PMID: 35434532
- Discovery of non-substrate, environmentally sensitive turn-on fluorescent probes for imaging HDAC8 in tumor cells and tissue slices. | Huang, C., et al. 2022. Bioorg Med Chem. 68: 116821. PMID: 35661851
- HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells. | Kim, JY., et al. 2022. Int J Mol Sci. 23: PMID: 35955780
- Histone deacetylase 8 inhibition prevents the progression of peritoneal fibrosis by counteracting the epithelial-mesenchymal transition and blockade of M2 macrophage polarization. | Zhou, X., et al. 2023. Front Immunol. 14: 1137332. PMID: 36911746
Inhibitor of:
Hat2, HDAC10, HDAC2, HDAC3, HDAC4, HDAC8, Hils1, IGF2AS, and SAP 130.Activator of:
4930557A04Rik, ELP3, HDA5, Histone cluster 1 H4G, MEAF6, and ZNF322A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PCI-34051, 10 mg | sc-364566 | 10 mg | $189.00 | |||
PCI-34051, 100 mg | sc-364566A | 100 mg | $1671.00 |