Molecular structure of Tubacin, CAS Number: 537049-40-4
Tubacin (CAS 537049-40-4)
See product citations (8)
Alternate Names:
N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide
Application:
Tubacin is a selective inhibitor of HDAC6 that reversibly inhibits α-tubulin deacetylation
CAS Number:
537049-40-4
Purity:
≥90%
Molecular Weight:
721.86
Molecular Formula:
C41H43N3O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2). Tubacin does not inhibit HDAC6 histone deacetylase activity. Instead, it reversibly inhibits alpha-tubulin deacetylation. Tubacin increases alpha-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression.
Tubacin (CAS 537049-40-4) References
- Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. | Kawada, J., et al. 2009. J Biol Chem. 284: 17102-17109. PMID: 19386607
- Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. | Namdar, M., et al. 2010. Proc Natl Acad Sci U S A. 107: 20003-8. PMID: 21037108
- Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. | Aldana-Masangkay, GI., et al. 2011. Leuk Lymphoma. 52: 1544-55. PMID: 21699378
- Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero. | Salmi, M., et al. 2013. Brain. 136: 2457-73. PMID: 23831613
- Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. | Lu, CY., et al. 2017. Int J Mol Sci. 18: PMID: 28468311
- Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway. | Saito, S., et al. 2017. PLoS One. 12: e0186615. PMID: 29045477
- Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities. | Ota, S., et al. 2018. Oncotarget. 9: 3172-3187. PMID: 29423038
- Growth Suppression of Glioma Cells Using HDAC6 Inhibitor, Tubacin. | Yin, C. and Li, P. 2018. Open Med (Wars). 13: 221-226. PMID: 29845122
- Involvement of HDAC6 in ischaemia and reperfusion-induced rat retinal injury. | Yuan, H., et al. 2018. BMC Ophthalmol. 18: 300. PMID: 30453928
- The histone deacetylase inhibitor tubacin mitigates endothelial dysfunction by up-regulating the expression of endothelial nitric oxide synthase. | Chen, J., et al. 2019. J Biol Chem. 294: 19565-19576. PMID: 31719145
- Improved early development potence of in vitro fertilization embryos by treatment with tubacin increasing acetylated tubulin of matured porcine oocytes. | Sun, J., et al. 2020. Mech Dev. 164: 103631. PMID: 32828904
- MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of α-tubulin acetylation. | Wang, X., et al. 2020. Cell Prolif. 53: e12911. PMID: 32985730
- Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation. | Nomura, Y., et al. 2021. Front Physiol. 12: 675724. PMID: 34220539
Inhibitor of:
HDAC, and HDAC6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tubacin, 1 mg | sc-362815 | 1 mg | $197.00 | |||
Tubacin, 5 mg | sc-362815A | 5 mg | $429.00 | |||
Tubacin, 50 mg | sc-362815B | 50 mg | $4249.00 | |||
Tubacin, 500 mg | sc-362815C | 500 mg | $10543.00 | |||
Tubacin, 1 g | sc-362815D | 1 g | $13674.00 |