Histone H3F3C Inhibitors
The designation Histone H3F3C Inhibitors pertains to a distinct class of chemical compounds intricately designed to modulate the activity of histone variant H3F3C. Histones are essential proteins involved in packaging DNA into structural units known as nucleosomes, playing a fundamental role in the regulation of gene expression. H3F3C is a specific variant of histone H3, and inhibitors within this class are engineered through principles grounded in medicinal chemistry. The primary objective of these inhibitors is to selectively interfere with the normal functions of H3F3C within cellular processes. The structural composition of Histone H3F3C Inhibitors is carefully tailored, often involving computational modeling and structure-activity relationship studies, to optimize their molecular configurations for precise binding to the target.
Histone H3F3C Inhibitors aim to disrupt the biochemical activities associated with H3F3C, contributing to a nuanced understanding of chromatin dynamics and epigenetic regulation. Researchers engaged in this field explore the three-dimensional structure of H3F3C and its binding interactions with inhibitors, aiming to decipher the intricate molecular mechanisms underlying inhibition. The study of Histone H3F3C Inhibitors holds broader implications for unraveling the complexities of epigenetic regulation, offering insights into the roles played by specific histone variants in shaping chromatin architecture and modulating gene expression patterns within cells. This research not only contributes to the understanding of H3F3C but also enhances our comprehension of the broader molecular landscape governing gene regulation in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor. By affecting DNA methylation patterns, it could hypothetically alter the transcriptional regulation of histone genes, including Histone H3F3C. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been shown to inhibit a number of kinases and may affect signaling pathways that regulate gene expression, including the expression of histone proteins. | ||||||
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
As a product inhibitor of methyltransferase reactions, elevated levels of S-Adenosylhomocysteine could potentially inhibit histone methylation and thus affect the expression of histone genes. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a specific inhibitor of the histone methyltransferase SUV39H1. By altering histone methylation, it could hypothetically impact the expression of other histone genes, including H3F3C. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor and has been shown to act as a regulator of epigenetic modifications, which could affect histone gene expression indirectly. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate copper, and since copper is a cofactor for some enzymes involved in chromatin remodeling, disulfiram could potentially affect the expression of histone genes, including H3F3C. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to affect various signaling pathways and may have epigenetic effects that could alter the expression of histone genes, including H3F3C. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase (HAT) activities, which could change the acetylation pattern of histones and potentially influence the expression of histone genes like H3F3C. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the major catechin in green tea, has been observed to have epigenetic effects that could potentially alter histone gene expression patterns. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide has been shown to inhibit NF-κB, a transcription factor that can regulate a variety of genes, potentially including those encoding for histones. | ||||||