Histone H2A.F Inhibitors
The chemical class known as Histone H2A.F Inhibitors encompasses a variety of compounds that indirectly influence the function of Histone H2A.F. This influence is exerted through the modulation of chromatin dynamics and histone modifications, crucial for the proper functioning of Histone H2A.F within the nucleosome structure of chromatin. These inhibitors work by changing the epigenetic environment, which in turn affects how Histone H2A.F interacts with DNA and other histone proteins.
Histone deacetylase inhibitors such as Trichostatin A, Vorinostat, Sodium butyrate, and Romidepsin increase the acetylation of histones. This hyperacetylated state leads to a more open and relaxed chromatin conformation, which reduces the ability of Histone H2A.F to tightly bind and maintain chromatin in a condensed state. The relaxation of chromatin not only affects the accessibility of DNA to transcription factors but also the overall stability of the nucleosome, which is partially maintained by the Histone H2A.F-DNA interaction. Compounds targeting DNA methylation and histone methylation, such as RG108 and BIX-01294, respectively, also play a significant role in the regulation of Histone H2A.F. By inhibiting these enzymes, these chemicals lead to alterations in the methylation landscape of chromatin. Changes in DNA methylation can result in decreased recruitment of Histone H2A.F to methylated regions of the genome, influencing chromatin organization. Similarly, inhibition of histone methylation results in a chromatin state that is less compact, further affecting Histone H2A.F's ability to bind and stabilize the nucleosome.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can lead to changes in chromatin structure and reduce Histone H2A.F's ability to condense chromatin. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
DNA-binding antibiotic that can displace histone proteins by binding to their sites on DNA, which may affect Histone H2A.F's ability to bind to DNA and stabilize chromatin structure. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Interferes with lysosomal activity and autophagy, which can lead to changes in chromatin dynamics and indirectly affect Histone H2A.F's role in chromatin structure. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor that can lead to DNA hypomethylation, affecting the recruitment of Histone H2A.F to methylated regions of the genome and its role in chromatin organization. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Aldehyde dehydrogenase inhibitor that can influence acetylation levels in cells, impacting Histone H2A.F's interaction with chromatin. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
Inhibitor of G9a histone methyltransferase that can lead to reduced histone methylation, impacting the chromatin compaction roles of histone proteins including Histone H2A.F. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Histone deacetylase inhibitor that can change chromatin structure, thereby potentially impacting the binding and function of Histone H2A.F in nucleosome organization. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Non-selective phosphodiesterase inhibitor that can alter cellular signaling pathways affecting chromatin structure and potentially Histone H2A.F's role in chromatin compaction. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Inhibitor of DNA methyltransferases and histone acetyltransferases, altering the epigenetic marks that guide Histone H2A.F's binding to chromatin. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
A potent histone deacetylase inhibitor that can broadly alter gene expression and chromatin structure, influencing Histone H2A.F's ability to maintain nucleosome stability. | ||||||