Histone H1B Activators
Chemical activators of Histone H1B can induce a more transcriptionally active chromatin state through the inhibition of histone deacetylases (HDACs). Trichostatin A, Vorinostat, Suberoylanilide Hydroxamic Acid (SAHA), Panobinostat, Romidepsin, Entinostat, Belinostat, Mocetinostat, Givinostat, and CUDC-101 all share a common mechanism of HDAC inhibition, which leads to an increase in the acetylation levels of histone proteins, including Histone H1B. The acetylation process neutralizes the positive charge on the histone tails, thereby weakening the interaction between histones and the negatively charged DNA backbone. As Histone H1B becomes acetylated, the chromatin structure transforms from a tightly packed to a more relaxed and open conformation. This open state is associated with an active transcriptional environment where transcription machinery has greater access to DNA, facilitating the expression of genes regulated by Histone H1B.
Furthermore, Sodium Butyrate and Valproic Acid are also known to function as HDAC inhibitors, leading to the acetylation and consequent functional activation of Histone H1B. The action of Sodium Butyrate results in a less condensed chromatin structure, while the effect of Valproic Acid similarly diminishes the interaction between the histones and DNA. Both chemicals thereby promote a chromatin architecture conducive to the initiation and progression of transcription. The uniform outcome of these chemical activators is the establishment of a chromatin environment that supports the transcriptional activation of genes associated with Histone H1B, without implying any potential for use beyond the described mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs). This inhibition allows acetylation of Histone H1B, which leads to an open chromatin structure and makes the DNA more accessible for transcription, thereby leading to the functional activation of Histone H1B in the context of gene expression regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Similar to Trichostatin A, Vorinostat is an HDAC inhibitor that results in increased acetylation of histones, including Histone H1B. The acetylation diminishes the histone-DNA interaction and activates transcriptional mechanisms, functionally activating Histone H1B. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor leading to the acetylation of Histone H1B. Increased acetylation results in a less compact chromatin structure, facilitating transcriptional activation and thereby functionally activating Histone H1B. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, an HDAC inhibitor, increases the acetylation level of histones, including Histone H1B. The acetylation reduces the positive charge on histones, weakening their interaction with the negatively charged phosphate groups of DNA, thus activating Histone H1B functionally. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Panobinostat is a potent HDAC inhibitor that leads to hyperacetylation of histones such as Histone H1B. This hyperacetylation is conducive to a transcriptionally active chromatin state, thereby functionally activating Histone H1B. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin selectively inhibits HDAC, inducing an increase in acetylated histones, including Histone H1B. The increased acetylation activates Histone H1B by promoting transcriptional activity through a more open chromatin structure. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is a selective HDAC inhibitor that leads to increased acetylation of Histone H1B. This acetylation activates Histone H1B by allowing a relaxed chromatin conformation that is permissive for transcriptional activation. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
Belinostat, an HDAC inhibitor, increases the acetylation of histones, including Histone H1B, thereby activating it. The acetylation promotes a transcriptionally active state of the chromatin, functionally activating Histone H1B. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is an HDAC inhibitor that increases acetylation levels of Histone H1B, among other histones, which activates Histone H1B's role in transcriptional activation due to the resulting less compact chromatin conformation. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat inhibits HDAC activity, which results in the acetylation and consequent functional activation of Histone H1B. This activation is due to the chromatin's transition to a more open state that facilitates gene transcription. | ||||||