Histone cluster 1 H4F Inhibitors
Histone cluster 1 H4F Inhibitors constitute a specialized class of chemical compounds designed to selectively impede the activity of histone cluster 1, focusing specifically on the H4F subtype. Histones are integral proteins in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H4F designation refers to a variant of histone H4, one of the core histones crucial for nucleosome assembly. As a specific variant within histone cluster 1, H4F becomes a subject of interest for researchers seeking to unravel the complexities of chromatin dynamics and gene regulation.
The development of Histone cluster 1 H4F Inhibitors necessitates a thorough understanding of the structural characteristics of histone H4F and its specific role within chromatin organization. These inhibitors are meticulously crafted for specificity, aiming to selectively bind to key regions of Histone cluster 1 H4F and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H4F, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a G9a histone methyltransferase inhibitor, potentially decreasing histone methylation, which could alter the expression of various genes, including those coding for histones. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is known to inhibit histone methyltransferase SUV39H1, potentially affecting chromatin structure and gene expression, including the regulation of histone gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which could lead to DNA demethylation and subsequent changes in gene expression patterns, potentially affecting histone gene expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108 is another DNA methyltransferase inhibitor that does not incorporate into DNA, potentially altering methylation patterns and gene expression, including that of histone genes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been shown to have an impact on various signaling pathways and may affect histone modification enzymes, potentially influencing gene expression including that of histones. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, has been found to have HDAC inhibitory activity, which could affect histone acetylation levels and, consequently, gene expression, including histone genes. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
MS-275 is an HDAC inhibitor that can modify the acetylation state of histones, potentially influencing the expression of various genes, including histone genes. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol has been reported to inhibit various signal transduction pathways and may impact histone modifications, potentially influencing histone gene regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that has been shown to affect DNA methylation and histone acetylation, which could potentially alter gene expression profiles, including those of histones. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
CAPE is known for its ability to inhibit NF-κB activation and also has HDAC inhibitory properties, potentially impacting gene expression, including histone gene regulation. | ||||||