Date published: 2026-5-16

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Histone cluster 1 H3C Inhibitors

Histone cluster 1 H3C Inhibitors constitute a specialized class of chemical compounds designed to selectively impede the activity of histone cluster 1, with a specific focus on the H3C subtype. Histones are crucial proteins in the organization of DNA within the nucleus, forming nucleosomes that serve as the structural foundation for chromatin. The H3C designation refers to a variant of histone H3, one of the core histones essential for nucleosome assembly. The H3C subtype represents a specific variant within histone cluster 1, making it a key point of interest for research aimed at unraveling the intricacies of chromatin dynamics and gene regulation.

The development of Histone cluster 1 H3C Inhibitors demands a comprehensive understanding of the structural characteristics of histone H3C and its specific role within chromatin organization. These inhibitors are meticulously crafted for specificity, aiming to selectively bind to key regions of Histone cluster 1 H3C and disrupt its normal functions. By employing these inhibitors in experimental contexts, researchers can explore the consequences of inhibiting this particular histone variant, providing valuable insights into chromatin remodeling and the intricate regulation of gene expression. The study of histones, including variants like H3C, significantly contributes to advancing our understanding of epigenetic mechanisms, offering crucial insights into the dynamic processes governing gene regulation and the complex orchestration of cellular functions at the chromatin level.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Panobinostat

404950-80-7sc-208148
10 mg
$200.00
9
(1)

Panobinostat is a histone deacetylase inhibitor, impacting chromatin structure and potentially influencing the acetylation status of histones, including H3C.

JIB 04

199596-05-9sc-397040
20 mg
$177.00
(0)

JIB-04 inhibits Jumonji histone demethylases, potentially impacting histone demethylation and the transcriptional regulation of genes, including H3C.

ACY-1215

1316214-52-4sc-507455
25 mg
$110.00
(0)

Rocilinostat is a histone deacetylase inhibitor, impacting chromatin structure and potentially affecting the acetylation status of histones, including H3C.

UNC0638

1255580-76-7sc-397012
10 mg
$315.00
(0)

UNC0638 inhibits G9a, a histone methyltransferase, potentially influencing the methylation status of histones and the expression of genes, including H3C.

GSK-J4

1373423-53-0sc-507551
100 mg
$1275.00
(0)

GSK-J4 inhibits lysine demethylase, potentially influencing histone demethylation and the transcriptional regulation of genes, including H3C.

EPZ6438

1403254-99-8sc-507456
1 mg
$66.00
(0)

EPZ-6438 targets EZH2, a histone methyltransferase, potentially impacting the methylation of histones and the expression of genes like H3C.

(S)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetamide

202590-98-5sc-501130
2.5 mg
$330.00
(0)

OTX015 is a bromodomain and extraterminal (BET) protein inhibitor, disrupting interactions between BET proteins and acetylated histones, potentially influencing gene expression.

GSK126

1346574-57-9sc-490133
sc-490133A
sc-490133B
1 mg
5 mg
10 mg
$92.00
$243.00
$306.00
(0)

GSK343 inhibits EZH2, potentially influencing histone methylation patterns and the transcriptional regulation of genes, including H3C.

C646

328968-36-1sc-364452
sc-364452A
10 mg
50 mg
$265.00
$944.00
5
(1)

C646 is a selective inhibitor of histone acetyltransferase, modulating the acetylation of histones and influencing the expression of associated genes, including H3C.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

Decitabine is a DNA methyltransferase inhibitor, potentially influencing DNA methylation patterns and the expression of genes, including H3C.