Date published: 2025-10-3

1-800-457-3801

SCBT Portrait Logo
Seach Input

HIP14L Activators

HIP14L, or Huntingtin Interacting Protein 14-Like, is a gene that encodes a protein closely related to HIP14, a member of the palmitoyl transferase family. HIP14L is involved in the process of palmitoylation, a post-translational modification where a palmitic acid is covalently attached to specific cysteine residues in proteins. This modification influences the trafficking, localization, stability, and function of the modified proteins.The HIP14L protein shares structural similarities with HIP14, including DHHC (Asp-His-His-Cys) domain, characteristic of palmitoyl acyltransferases (PATs). This domain is essential for the enzyme's catalytic activity in transferring palmitate to substrate proteins. Palmitoylation by HIP14L is crucial for regulating various cellular processes, including signal transduction, protein sorting, and membrane dynamics.

While HIP14 is known for its interaction with huntingtin, the protein mutated in Huntington's disease, the specific roles and interactions of HIP14L are less well understood. However, given its enzymatic function and similarity to HIP14, HIP14L is likely to interact with a range of substrates, impacting neuronal function and playing a role in neurodegenerative disorders.Studies suggest that dysregulation of palmitoylation enzymes like HIP14L can impact neuronal signaling and health, contributing to the pathogenesis of neurological diseases. Understanding HIP14L's specific functions and substrates could shed light on these processes and offer targets for intervention.

SEE ALSO...

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A DNA methyltransferase inhibitor, potentially altering gene expression and affecting proteins like HIP14L.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

A histone deacetylase inhibitor, which could affect chromatin remodeling and possibly influence the expression of genes like HIP14L.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

A proteasome inhibitor that may stabilize various proteins, potentially including HIP14L.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

An inhibitor of protein biosynthesis, possibly affecting the overall protein expression levels, including HIP14L.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

An mTOR inhibitor, influencing cellular growth and protein synthesis, possibly impacting HIP14L.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$30.00
$52.00
$122.00
$367.00
25
(3)

Disrupts ER to Golgi transport, potentially influencing a range of proteins including HIP14L.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Activates adenylate cyclase, increasing cAMP levels and potentially affecting cellular proteins.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

A glycolysis inhibitor, impacting energy metabolism and potentially influencing protein function and stability.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

A general kinase inhibitor, potentially affecting signaling pathways that might impact HIP14L.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Known for affecting lysosomal function, potentially impacting the turnover of various cellular proteins.