HIP14L, or Huntingtin Interacting Protein 14-Like, is a gene that encodes a protein closely related to HIP14, a member of the palmitoyl transferase family. HIP14L is involved in the process of palmitoylation, a post-translational modification where a palmitic acid is covalently attached to specific cysteine residues in proteins. This modification influences the trafficking, localization, stability, and function of the modified proteins.The HIP14L protein shares structural similarities with HIP14, including DHHC (Asp-His-His-Cys) domain, characteristic of palmitoyl acyltransferases (PATs). This domain is essential for the enzyme's catalytic activity in transferring palmitate to substrate proteins. Palmitoylation by HIP14L is crucial for regulating various cellular processes, including signal transduction, protein sorting, and membrane dynamics.
While HIP14 is known for its interaction with huntingtin, the protein mutated in Huntington's disease, the specific roles and interactions of HIP14L are less well understood. However, given its enzymatic function and similarity to HIP14, HIP14L is likely to interact with a range of substrates, impacting neuronal function and playing a role in neurodegenerative disorders.Studies suggest that dysregulation of palmitoylation enzymes like HIP14L can impact neuronal signaling and health, contributing to the pathogenesis of neurological diseases. Understanding HIP14L's specific functions and substrates could shed light on these processes and offer targets for intervention.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, potentially altering gene expression and affecting proteins like HIP14L. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor, which could affect chromatin remodeling and possibly influence the expression of genes like HIP14L. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that may stabilize various proteins, potentially including HIP14L. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
An inhibitor of protein biosynthesis, possibly affecting the overall protein expression levels, including HIP14L. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor, influencing cellular growth and protein synthesis, possibly impacting HIP14L. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts ER to Golgi transport, potentially influencing a range of proteins including HIP14L. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels and potentially affecting cellular proteins. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
A glycolysis inhibitor, impacting energy metabolism and potentially influencing protein function and stability. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A general kinase inhibitor, potentially affecting signaling pathways that might impact HIP14L. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known for affecting lysosomal function, potentially impacting the turnover of various cellular proteins. |