Date published: 2025-10-7

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HIF Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of HIF monoclonal antibodies for studying hypoxia-inducible factors (HIFs) in various research applications. HIF Antibodies are compatible with western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). HIFs are critical transcription factors that regulate cellular responses to low oxygen levels, playing a vital role in processes such as angiogenesis, metabolism, and cell survival. HIF dysregulation is implicated in various diseases, including cancer, making HIFs a significant focus of biomedical research. Understanding the function and regulation of HIFs can provide insights into therapeutic strategies for hypoxia-related conditions. HIF Antibodies enable precise detection and analysis of HIF expression patterns across different tissue types and experimental conditions. Researchers investigating oxygen-dependent cellular mechanisms rely on specific molecular tools to advance their work. Santa Cruz Biotechnology monoclonal antibodies support the scientific community by facilitating detailed investigations of hypoxia signaling pathways and their implications in health and disease.

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HIF Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

EPAS-1/HIF-2 alpha Antibody (190b)

sc-13596mouse IgG1 κ(h)WB, IP, IF, IHC(P), ELISAm, r, h
61
(12)

EPAS-1/HIF-2 alpha Antibody (A-5)

sc-46691mouse IgG2b κ556-865 (h)WB, IP, IF, ELISAh
20
(7)

HIF1a Antibody (28b)

sc-13515mouse IgG1 κ329-530 (h)WB, IP, IF, IHC(P)m, r, h
288
(90)

HIF1a Antibody (H1alpha 67)

sc-53546mouse IgG2b κ432-528 (h)WB, IP, IF, IHC(P)m, r, h
194
(23)

HIF1a Antibody (3C144)

sc-71247mouse IgG1 κ329-530 (h)WB, IP, IFm, r, h
18
(2)

HIF-3α Antibody (E-8)

sc-390933mouse IgM κ612-639 (m)WB, IP, IF, ELISAm, r, h
3
(2)

HIF-3α Antibody (D-7)

sc-390769mouse IgG2b κ619-640 (m)WB, IP, IF, ELISAm, r, h

new

(1)

HIF CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HIF1a CRISPR/Cas9 KO Plasmid (h2)

sc-400036-KO-2hGene KnockoutGFP
1
(0)

HIF1a HDR Plasmid (h2)

sc-400036-HDR-2hHomology Directed RepairPuromycin
1
(0)

HIF1a Double Nickase Plasmid (h)

sc-400036-NIChGene KnockoutPuromycin
1
(0)

HIF1a Double Nickase Plasmid (h2)

sc-400036-NIC-2hGene KnockoutPuromycin
1
(0)

HIF1a CRISPR/Cas9 KO Plasmid (m2)

sc-420856-KO-2mGene KnockoutGFP
1
(0)

HIF1a HDR Plasmid (m2)

sc-420856-HDR-2mHomology Directed RepairPuromycin
1
(0)

HIF1a Double Nickase Plasmid (m)

sc-420856-NICmGene KnockoutPuromycin
1
(0)

HIF1a Double Nickase Plasmid (m2)

sc-420856-NIC-2mGene KnockoutPuromycin
1
(0)

HIF-3α CRISPR/Cas9 KO Plasmid (h)

sc-403487hGene KnockoutGFP0
(0)

HIF-3α HDR Plasmid (h)

sc-403487-HDRhHomology Directed RepairPuromycin0
(0)

HIF-3α Double Nickase Plasmid (h)

sc-403487-NIChGene KnockoutPuromycin0
(0)

HIF-3α Double Nickase Plasmid (h2)

sc-403487-NIC-2hGene KnockoutPuromycin0
(0)

HIF-3α CRISPR/Cas9 KO Plasmid (m)

sc-424712mGene KnockoutGFP0
(0)

HIF-3α HDR Plasmid (m)

sc-424712-HDRmHomology Directed RepairPuromycin0
(0)

HIF-3α Double Nickase Plasmid (m)

sc-424712-NICmGene KnockoutPuromycin0
(0)

HIF-3α Double Nickase Plasmid (m2)

sc-424712-NIC-2mGene KnockoutPuromycin0
(0)

HIF CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HIF1a CRISPR Activation Plasmid (h)

sc-400036-ACThGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a CRISPR Activation Plasmid (h2)

sc-400036-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a Lentiviral Activation Particles (h)

sc-400036-LAChGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a Lentiviral Activation Particles (h2)

sc-400036-LAC-2hGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a CRISPR Activation Plasmid (m)

sc-420856-ACTmGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a CRISPR Activation Plasmid (m2)

sc-420856-ACT-2mGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a Lentiviral Activation Particles (m)

sc-420856-LACmGene ActivationPuro, Blast, Hygro
1
(0)

HIF1a Lentiviral Activation Particles (m2)

sc-420856-LAC-2mGene ActivationPuro, Blast, Hygro
1
(0)

HIF-3α CRISPR Activation Plasmid (h)

sc-403487-ACThGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α CRISPR Activation Plasmid (h2)

sc-403487-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α Lentiviral Activation Particles (h)

sc-403487-LAChGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α Lentiviral Activation Particles (h2)

sc-403487-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α CRISPR Activation Plasmid (m)

sc-424712-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α CRISPR Activation Plasmid (m2)

sc-424712-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α Lentiviral Activation Particles (m)

sc-424712-LACmGene ActivationPuro, Blast, Hygro0
(0)

HIF-3α Lentiviral Activation Particles (m2)

sc-424712-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HIF siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HIF1a siRNA (h)

sc-35561hGene SilencingN/A
195
(4)

HIF1a siRNA (h2)

sc-44225hGene SilencingN/A
21
(0)

HIF1a shRNA Plasmid (h)

sc-35561-SHhGene SilencingPuromycin
195
(4)

HIF1a shRNA Plasmid (h2)

sc-44225-SHhGene SilencingPuromycin
21
(0)

HIF1a shRNA (h) Lentiviral Particles

sc-35561-VhGene SilencingPuromycin
195
(4)

HIF1a shRNA (h2) Lentiviral Particles

sc-44225-VhGene SilencingPuromycin
21
(0)

HIF1a siRNA (m)

sc-35562mGene SilencingN/A
62
(0)

HIF1a siRNA (m2)

sc-44308mGene SilencingN/A
3
(0)

HIF1a shRNA Plasmid (m)

sc-35562-SHmGene SilencingPuromycin
62
(0)

HIF1a shRNA Plasmid (m2)

sc-44308-SHmGene SilencingPuromycin
3
(0)

HIF1a shRNA (m) Lentiviral Particles

sc-35562-VmGene SilencingPuromycin
62
(0)

HIF1a shRNA (m2) Lentiviral Particles

sc-44308-VmGene SilencingPuromycin
3
(0)

HIF1a siRNA (r)

sc-45919rGene SilencingN/A
32
(0)

HIF1a shRNA Plasmid (r)

sc-45919-SHrGene SilencingPuromycin
32
(0)

HIF1a shRNA (r) Lentiviral Particles

sc-45919-VrGene SilencingPuromycin
32
(0)

HIF1a siRNA (chicken)

sc-156142avianGene SilencingN/A
1
(0)

HIF1a shRNA Plasmid (chicken)

sc-156142-SHchickenGene SilencingPuromycin
1
(0)

HIF1a shRNA (chicken) Lentiviral Particles

sc-156142-VchickenGene SilencingPuromycin
1
(0)

HIF1a siRNA (bovine)

sc-270450bovineGene SilencingN/A
1
(0)

HIF1a shRNA Plasmid (bovine)

sc-270450-SHbovineGene SilencingPuromycin
1
(0)

HIF1a shRNA (bovine) Lentiviral Particles

sc-270450-VbovineGene SilencingPuromycin
1
(0)

HIF-3α siRNA (h)

sc-38167hGene SilencingN/A
2
(0)

HIF-3α shRNA Plasmid (h)

sc-38167-SHhGene SilencingPuromycin
2
(0)

HIF-3α shRNA (h) Lentiviral Particles

sc-38167-VhGene SilencingPuromycin
2
(0)

HIF-3α siRNA (m)

sc-38168mGene SilencingN/A0
(0)

HIF-3α shRNA Plasmid (m)

sc-38168-SHmGene SilencingPuromycin0
(0)

HIF-3α shRNA (m) Lentiviral Particles

sc-38168-VmGene SilencingPuromycin0
(0)

HIF Transfected Lysates

Empty Table HeaderProduct NameCATALOG #SpeciesCONTROL ANTIBODYCitationsRATING

HIF1a (m): 293T Lysate

sc-120778m
1
(1)

HIF Oligonucleotides

Empty Table HeaderProduct NameCONSENSUS CAT. #MUTANT CAT. #MUTANT CONSENSUSBINDING MOTIFCitationsRATING

HIF-1α consensus oligonucleotide

sc-2625sc-26265'-TCT GTA CGT GAC CAC ACT CAC CTC-3'"CGT"→"AAA"
27
(1)