EPAS-1/HIF-2 alpha Antibody (A-5): sc-46691
- EPAS-1/HIF-2 alpha Antibody (A-5) is a mouse monoclonal IgG2b κ, cited in 20 publications, provided at 200 µg/ml
- raised against amino acids 556-865 of EPAS-1 of human origin
- EPAS-1/HIF-2 alpha Antibody (A-5) is recommended for detection of EPAS-1 of human origin by WB, IP, IF and ELISA
- Anti-EPAS-1/HIF-2 alpha Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-46691 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for EPAS-1/HIF-2 alpha Antibody (A-5). This work is in progress.
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SEE ALSO...
EPAS-1 Antibody (A-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects EPAS-1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EPAS-1 (A-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EPAS-1, also known as HIF-2α, plays a crucial role in cellular responses to hypoxia, which is a condition characterized by low oxygen levels. EPAS-1 is primarily located in the nucleus, where EPAS-1 functions as a transcription factor that regulates the expression of genes involved in critical processes such as angiogenesis, erythropoiesis, and glucose metabolism. EPAS-1′s ability to form heterodimers with other hypoxia-inducible factors, such as HIF-1β (Arnt 1), allows EPAS-1 to bind to hypoxia-responsive elements in target gene promoters, thereby facilitating the transcription of genes that help cells adapt to oxygen deprivation. Understanding EPAS-1 function and localization is vital, as EPAS-1 dysregulation has been implicated in various pathological conditions, including cancer and cardiovascular diseases, where oxygen supply is often compromised.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EPAS-1/HIF-2 alpha Antibody (A-5) | sc-46691 | 200 µg/ml | $316.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) X | sc-46691 X | 200 µg/0.1 ml | $316.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) AC | sc-46691 AC | 500 µg/ml, 25% agarose | $416.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) HRP | sc-46691 HRP | 200 µg/ml | $316.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) FITC | sc-46691 FITC | 200 µg/ml | $330.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) PE | sc-46691 PE | 200 µg/ml | $343.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 488 | sc-46691 AF488 | 200 µg/ml | $357.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 546 | sc-46691 AF546 | 200 µg/ml | $357.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 594 | sc-46691 AF594 | 200 µg/ml | $357.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 647 | sc-46691 AF647 | 200 µg/ml | $357.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 680 | sc-46691 AF680 | 200 µg/ml | $357.00 | |||
EPAS-1/HIF-2 alpha Antibody (A-5) Alexa Fluor® 790 | sc-46691 AF790 | 200 µg/ml | $357.00 |