HEBP2 Activators
HEBP2 Activators are a unique class of compounds that function by influencing the phosphorylation state and functional activity of HEBP2, a regulator involved in iron metabolism. The compounds Forskolin, IBMX, EGF, PMA, Anisomycin, Calyculin A, A23187, Phosphatidic acid, Okadaic acid, and S1P all interact with various signaling pathways that can enhance the functional activity of HEBP2. Forskolin and IBMX, for instance, are known to function by increasing cAMP levels, which in turn activate the PKA pathway, leading to the phosphorylation and activation of HEBP2. Similarly, EGF, Anisomycin, and Phosphatidic acid are potent activators of the EGFR, p38 MAPK, and mTOR pathways respectively,all of which can phosphorylate and activate HEBP2.
Other HEBP2 activators such as PMA and S1P function by activating the PKC and PI3K-Akt pathways respectively, which can also lead to the phosphorylation and activation of HEBP2. Calyculin A and Okadaic acid, on the other hand, are inhibitors of protein phosphatases 1 and 2A. The inhibition of these phosphatases prevents the dephosphorylation of HEBP2, thereby maintaining its activated state. Similarly, A23187 functions by increasing intracellular calcium levels, which can activate the Calcineurin pathway. Activation of this pathway can lead to the dephosphorylation and activation of NFAT, which may interact with HEBP2 to enhance its function in iron metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, which leads to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can trigger the Protein Kinase A (PKA) pathway, that can phosphorylate and activate HEBP2, enhancing its function in iron metabolism. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor that prevents the breakdown of cAMP, leading to its accumulation. The increased cAMP can activate the PKA pathway, thereby enhancing the functional activity of HEBP2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC), which can phosphorylate and activate HEBP2, thereby enhancing its function in iron metabolism. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the p38 MAPK pathway. Activation of this pathway can lead to the phosphorylation and activation of HEBP2, enhancing its role in cellular iron homeostasis. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). The inhibition of these phosphatases can prevent the dephosphorylation of HEBP2, maintaining its activated state and enhancing its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can activate the Calcineurin pathway. Activation of this pathway can lead to the dephosphorylation and activation of NFAT, which may interact with HEBP2 to enhance its function in iron metabolism. | ||||||
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $104.00 $239.00 $409.00 | ||
Phosphatidic acid is a lipid second messenger that activates the mTOR pathway. Activation of mTOR can lead to the phosphorylation and activation of HEBP2, enhancing its function in cellular iron homeostasis. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases can prevent the dephosphorylation of HEBP2, maintaining its activated state and enhancing its function. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that activates the S1P receptor, leading to the activation of the PI3K-Akt pathway. Activation of this pathway can lead to the phosphorylation and activation of HEBP2, enhancing its function in iron metabolism. | ||||||