Date published: 2025-10-15

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HD-PTP Activators

The chemical class known as HD-PTP Activators refers to a group of compounds or molecules that have the capability to enhance the activity or function of the enzyme HD-PTP, also known as histidine phosphatase. HD-PTP is a protein tyrosine phosphatase enzyme encoded by the PTPN23 gene, and it plays a crucial role in various cellular processes. Its primary function is the dephosphorylation of tyrosine residues in proteins, which can have a profound impact on cell signaling, regulation of cellular processes, and overall cell function.

Activation of HD-PTP by these activators can modulate signal transduction pathways and cellular responses by regulating the phosphorylation status of specific proteins. These activators may bind to HD-PTP directly or indirectly, leading to increased catalytic activity or altered substrate specificity. By doing so, they can influence processes such as cell growth, differentiation, migration, and intracellular communication. HD-PTP activation is an active area of research in cell biology and signal transduction. In summary, HD-PTP Activators represent a class of compounds that can enhance the enzymatic activity of HD-PTP, a protein tyrosine phosphatase involved in regulating cellular signaling pathways. Their ability to modulate tyrosine phosphorylation events within cells makes them important molecules in the study of cell biology and signal transduction processes. Further research into these activators may provide valuable insights into their applications in various cellular contexts.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

These compounds inhibit protein degradation and might increase HD-PTP levels due to reduced proteasomal degradation.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

These compounds can affect gene expression broadly and may upregulate HD-PTP as part of changes in chromatin structure.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR inhibitors affect cellular growth pathways, which could intersect with HD-PTP regulation.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

DNA damage can lead to cellular stress responses that may include upregulation of HD-PTP.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$30.00
$60.00
$93.00
27
(1)

Oxidative stress is known to modulate various signaling pathways, potentially affecting HD-PTP expression.

Cobalt(II) chloride

7646-79-9sc-252623
sc-252623A
5 g
100 g
$63.00
$173.00
7
(1)

Hypoxia-inducible factors (HIFs) may regulate HD-PTP under low oxygen conditions.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

As a regulator of gene expression, retinoic acid could potentially upregulate HD-PTP.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium impacts the Wnt signaling pathway, which might intersect with pathways regulating HD-PTP expression.