HCS Activators
HCS Activators are a diverse class of compounds that enhance the functional activity of the protein known as HCS. These activators work through various signaling pathways and biological processes directly involved with HCS. For instance, Forskolin and Epinephrine both target the adenylate cyclase pathway resulting in elevated cAMP levels, which in turn activate PKA. PKA can phosphorylate HCS, bolstering its activity. Similarly, PIP3 facilitates the activation of AKT signaling, which regulates many cellular functions that involve HCS. The phosphorylation of substrates by AKT that interact with HCS can lead to an enhancement of HCS's functionality. Ionomycin, which increases intracellular calcium levels, can indirectly activate calcium-sensitive pathways, leading to the phosphorylation or allosteric activation of HCS.
Furthermore, compounds like Curcumin and Resveratrol activate transcription factors and sirtuins, respectively, with downstream effects that amplify HCS activity by increasing the interaction of HCS with other signaling components. Nitric oxide donors, such as Sodium Nitroprusside, stimulate guanylyl cyclase to produce cGMP, which activates PKG.Activated PKG can phosphorylate proteins that directly increase the activity of HCS. Sphingosine-1-phosphate and Lysophosphatidic acid both activate G-protein-coupled receptors, triggering signaling cascades that lead to the regulation of HCS, such as its translocation and interaction with signaling complexes, which can enhance its function. Thapsigargin, by inhibiting SERCA, raises cytosolic calcium levels and activates downstream kinases that can increase HCS activity. Moreover, Prostaglandin E2 interacts with EP receptors to activate adenylate cyclase or mobilize calcium, both pathways leading to an enhancement of HCS's activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing intracellular levels of cAMP. Elevated cAMP enhances the activity of HCS by facilitating the downstream activation of PKA, which can phosphorylate and increase the functional activity of HCS. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, leading to adenylate cyclase activation and cAMP production. This increase in cAMP promotes PKA activation, which in turn can phosphorylate HCS, enhancing its activity. | ||||||
PIT 1 | 53501-41-0 | sc-361293 sc-361293A | 10 mg 50 mg | $138.00 $607.00 | ||
PIP3 is produced by PI3K activation and can activate the AKT signaling pathway, which is known to regulate numerous cellular processes including those involving HCS. AKT can phosphorylate substrates that interact with HCS, enhancing its function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, indirectly activating calcium-sensitive signaling pathways that can enhance the activity of HCS through phosphorylation or allosteric activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate transcription factors such as NF-kB, which has downstream effects on cellular signaling pathways involving HCS, enhancing its activity through increased expression of signaling components that interact with HCS. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate proteins that modulate the activity of HCS, leading to an enhancement of HCS function through improved stability and interaction with cofactors. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $42.00 $83.00 $155.00 | 7 | |
Nitric oxide donors release NO, which can stimulate guanylyl cyclase to produce cGMP, activating PKG. PKG can then phosphorylate target proteins that modulate the activity of HCS, leading to its functional enhancement. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) activates S1P receptors, which can initiate signaling cascades that involve the regulation of HCS activity, including its translocation and interaction with signaling complexes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels which can activate downstream calcium-sensitive kinases that enhance HCS activity. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G-protein-coupled receptors (EP receptors), leading to the activation of adenylate cyclase or calcium mobilization, both of which can enhance HCS activity through PKA or calcium-dependent protein kinases. | ||||||