Molecular structure of PIT 1, CAS Number: 53501-41-0
PIT 1 (CAS 53501-41-0)
Application:
PIT 1 is an apoptosis inducing selective PIP3 antagonist
CAS Number:
53501-41-0
Molecular Weight:
351.76
Molecular Formula:
C14H10ClN3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PIT 1 functions as a potent and selective inhibitor of a specific enzyme. It acts by binding to the active site of the enzyme, preventing its normal function and disrupting the biochemical pathways in which it is involved. This disruption leads to a cascade of downstream effects, altering cellular processes and signaling pathways. By inhibiting this enzyme, PIT 1 can be used to study the specific biological functions and pathways in which the enzyme is involved. Its mechanism of action involves interfering with the enzyme′s ability to catalyze specific reactions, ultimately providing insights into the molecular mechanisms underlying various cellular processes.
PIT 1 (CAS 53501-41-0) References
- Inhibition of cell migration by PITENINs: the role of ARF6. | Miao, B., et al. 2012. Oncogene. 31: 4317-32. PMID: 22179837
- Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose. | Manna, P. and Jain, SK. 2014. Cell Physiol Biochem. 33: 1197-204. PMID: 24752192
- Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole. | Kommagalla, Y., et al. 2014. Medchemcomm. 5: 1359-1363. PMID: 25505943
- The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. | Bonandi, E., et al. 2017. Drug Discov Today. 22: 1572-1581. PMID: 28676407
- Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. | Bakhti, M., et al. 2022. Nat Commun. 13: 4540. PMID: 35927244
- LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2. | Wang, H., et al. 2022. Cell Death Discov. 8: 449. PMID: 36344496
Inhibitor of:
Akt, and Ser/Thr Protein Kinase.Activator of:
HCS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIT 1, 10 mg | sc-361293 | 10 mg | $141.00 | |||
PIT 1, 50 mg | sc-361293A | 50 mg | $619.00 |