Date published: 2025-10-11

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Hck Inhibitors

Hck inhibitors form a distinct chemical class known for their capacity to influence the activity of the Hck protein kinase. Hck, an abbreviation for Hematopoietic cell kinase, is a vital member of the Src family of non-receptor protein tyrosine kinases. These kinases play pivotal roles in intracellular signaling pathways, regulating various cellular processes including cell growth, differentiation, proliferation, and survival. Hck is predominantly expressed in hematopoietic cells, such as macrophages, monocytes, and neutrophils, where it plays a critical role in immune cell signaling. Hck inhibitors are meticulously engineered compounds designed to interact with the ATP-binding pocket located within the Hck kinase domain. This interaction disrupts the binding of ATP to the enzyme, effectively acting as molecular regulators that curtail its signaling activities. Structurally, Hck inhibitors are intricately crafted molecules with a specific shape that snugly fits into the ATP-binding site of the Hck kinase domain. This interference obstructs the transfer of phosphate groups to tyrosine residues on target proteins, which is a pivotal step in intracellular signaling cascades. By inhibiting Hck, these compounds possess the potential to disrupt downstream pathways linked to immune cell activation and inflammation. While Hck inhibitors have generated significant interest within research contexts for their utility in dissecting immune cell signaling and unraveling the role of Hck in various diseases. Researchers are actively investigating the potential of Hck inhibitors in conditions where Hck dysregulation is implicated, such as specific hematological malignancies and inflammatory disorders, in order to gain a deeper understanding of their utility.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PP 2

172889-27-9sc-202769
sc-202769A
1 mg
5 mg
$92.00
$223.00
30
(1)

PP 2 is distinguished by its unique reactivity as an acid halide, exhibiting a propensity for nucleophilic acyl substitution reactions. Its electronic structure promotes strong electrophilic character, enabling rapid interactions with a variety of nucleophiles. The compound's steric configuration influences reaction kinetics, leading to selective pathways. Furthermore, PP 2 demonstrates intriguing solvation dynamics, which can modulate its reactivity in different solvent environments, enhancing its versatility in synthetic applications.

PP121

1092788-83-4sc-301605
5 mg
$139.00
1
(0)

PP121 is characterized by its exceptional electrophilic nature as an acid halide, facilitating swift nucleophilic attacks. Its unique steric arrangement allows for selective reactivity, influencing the formation of specific products. The compound exhibits notable stability in various solvent systems, which can significantly alter its reactivity profile. Additionally, PP121's interaction with nucleophiles is governed by distinct kinetic parameters, making it a compelling subject for mechanistic studies in organic synthesis.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$25.00
$117.00
$209.00
27
(1)

Targets BCR-ABL kinase, inhibiting tyrosine kinase activity and blocking cell proliferation, studied in the research of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs).

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Inhibits multiple kinases, including RAF and VEGFR, disrupting signaling pathways in cancer cells.

Erlotinib, Free Base

183321-74-6sc-396113
sc-396113A
sc-396113B
sc-396113C
sc-396113D
500 mg
1 g
5 g
10 g
100 g
$85.00
$132.00
$287.00
$495.00
$3752.00
42
(0)

Targets EGFR tyrosine kinase, preventing cell division and growth, prescribed for non-small cell lung cancer and pancreatic cancer therapy.

Lapatinib

231277-92-2sc-353658
100 mg
$412.00
32
(1)

Dual inhibitor of EGFR and HER2 kinases, hindering receptor activation and signaling in HER2-positive breast cancer.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Blocks multiple kinases including BCR-ABL, Src, and c-KIT, used for CML and acute lymphoblastic leukemia (ALL).

Vemurafenib

918504-65-1sc-364643
sc-364643A
10 mg
50 mg
$115.00
$415.00
11
(1)

Targets mutated BRAF kinase, inhibiting the MAPK pathway, approved for melanoma with BRAF V600E mutation.

Palbociclib

571190-30-2sc-507366
50 mg
$315.00
(0)

Inhibits CDK4/6 kinases, preventing cell cycle progression, prescribed for hormone receptor-positive breast cancer.

Gefitinib

184475-35-2sc-202166
sc-202166A
sc-202166B
sc-202166C
100 mg
250 mg
1 g
5 g
$62.00
$112.00
$214.00
$342.00
74
(2)

Targets EGFR tyrosine kinase, blocking cell growth signaling, used for non-small cell lung cancer research.