Molecular structure of PP121, CAS Number: 1092788-83-4
PP121 (CAS 1092788-83-4)
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Alternate Names:
1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Application:
PP121 is an inhibitor of c-Abl, PI 3-kinase, PDGFR, Hck, FRAP, Flk-1, SRC, and DNA-PK
CAS Number:
1092788-83-4
Molecular Weight:
319.36
Molecular Formula:
C17H17N7
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PP121 has been shown to be an inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits c-Abl (IC50 of 18 nM), PI 3-kinase (IC50 of < 0.06 μM), PDGFR (IC50 of 2 nM), Hck (IC50 of 8 nM), FRAP (IC50 of 10 nM), Flk-1 (IC50 of 12 nM), SRC (IC50 of 14 nM), and DNA-PK (IC50 of < 0.06 μM). PP121 does not affect other serine-threonine protein kinases. PP-121 potently inhibits the proliferation of a subset of the tumor cell lines by direct inhibition of PI 3-kinase and FRAP.
Inhibitor of:
c-Abl, DNA-PK, Flk-1, Hck, mTOR, PDGFR, PI 3-kinase, and SRC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP121, 5 mg | sc-301605 | 5 mg | $139.00 |