Haptoglobin Activators
The term Haptoglobin Activators refers to a class of chemical compounds with the unique ability to interact with and modulate the activity of haptoglobin, a glycoprotein primarily found in the blood plasma and produced by the liver. Haptoglobin plays a critical role in the innate immune system and homeostasis by binding to free hemoglobin released into the bloodstream due to hemolysis (the breakdown of red blood cells). Hemoglobin is a highly reactive molecule, and when released into circulation, it can lead to oxidative stress and tissue damage. Haptoglobin functions as a hemoglobin scavenger, forming a complex with free hemoglobin and preventing its harmful effects. Haptoglobin activators are compounds that can influence the binding affinity or other properties of haptoglobin, impacting its ability to sequester hemoglobin and maintain the overall health of the organism.
The mechanism of action of haptoglobin activators typically involves their capacity to enhance the formation of haptoglobin-hemoglobin complexes or modulate the stability of these complexes. This interaction is crucial in preventing hemoglobin-induced oxidative damage and maintaining iron homeostasis. Some haptoglobin activators may increase the binding affinity of haptoglobin for hemoglobin, thus promoting more efficient hemoglobin clearance, while others might affect the conformational changes or structural properties of haptoglobin, influencing its ability to interact with hemoglobin. Understanding the properties and effects of haptoglobin activators is important in the context of hemolysis and its associated consequences, such as oxidative stress and iron overload. It sheds light on the mechanisms that organisms employ to mitigate these challenges and maintain systemic equilibrium.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, is known for its anti-inflammatory and antioxidant properties. It may enhance Haptoglobin expression by reducing oxidative stress and inflammation, thereby modulating its activity indirectly. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes and berries, is recognized for its antioxidant properties. It could potentially upregulate Haptoglobin expression in response to oxidative stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in many fruits and vegetables, exhibits antioxidant and anti-inflammatory effects. It may influence Haptoglobin levels by mitigating oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, this catechin is noted for its antioxidant properties. It may indirectly affect Haptoglobin activity by reducing oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A compound in cruciferous vegetables, sulforaphane is known for its antioxidant and anti-inflammatory effects, potentially influencing Haptoglobin expression. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As an antioxidant, N-Acetyl-L-cysteine may modulate Haptoglobin activity by mitigating oxidative stress and inflammation. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
An essential vitamin with antioxidant properties, it may play a role in enhancing Haptoglobin expression under oxidative stress conditions. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $26.00 $52.00 $124.00 $326.00 | 3 | |
DL-α-Tocopherol may indirectly influence Haptoglobin levels by reducing oxidative damage. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc, an essential mineral, can have an indirect effect on Haptoglobin expression due to its role in immune function and oxidative stress response. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
An essential micronutrient with antioxidant properties, selenium might influence Haptoglobin activity indirectly. | ||||||