HA-probe Activators
The term HA-probe Activators refers to a group of compounds that, although not directly targeting the HA-probe antibody or its epitope within the influenza hemagglutinin (HA) protein, have the to modulate cellular processes associated with influenza virus infection. The selected compounds encompass a range of antiviral mechanisms, including interference with viral entry, replication, and host immune response. Arbidol, for instance, directly interacts with viral HA, its fusion with host cell membranes and impeding the initiation of infection. Zanamivir and oseltamivir inhibit neuraminidase, indirectly affecting HA-mediated entry and limiting viral spread. Amantadine disrupts the acidification of endosomes, impacting the fusion activity of HA during viral entry.
Compounds like echinacea extract and quercetin, while not directly targeting HA, may enhance the host immune response against influenza infection, influencing the overall outcome of viral interactions. Interferon-alpha activates host cell defenses, impacting processes related to HA function. The broad-spectrum antiviral ribavirin, camostat mesilate, and the immunomodulatory agent Poly I:C can also impact influenza virus replication, indirectly affecting HA-related processes. N-acetylcysteine (NAC) and tilorone hydrochloride, with antioxidant and antiviral properties, may modulate host cell responses, impacting HA and other viral proteins. While not exhaustive, this class of compounds showcases the diverse strategies employed to modulate cellular processes associated with influenza virus infection, indirectly influencing the activities related to the HA protein and providing avenues for further investigation into antiviral interventions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arbidol Hydrochloride | 131707-23-8 | sc-210834 | 10 mg | $204.00 | ||
Arbidol is an antiviral agent that inhibits virus-cell fusion, potentially influencing the entry of influenza virus. It interacts with the viral hemagglutinin (HA) glycoprotein, preventing its fusion with the host cell membrane and blocking the initiation of viral infection. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $39.00 $147.00 | ||
Amantadine is an antiviral agent that targets the M2 ion channel of influenza A viruses. By inhibiting the M2 channel, amantadine disrupts the acidification of endosomes, impacting the fusion activity of the viral HA protein during entry into host cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has antiviral properties and may modulate cellular signaling pathways related to immune response. While its specific impact on HA is indirect, quercetin can influence host cell responses that may contribute to the antiviral defense against influenza infection. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin is a nucleoside analog with broad-spectrum antiviral activity. It can affect viral replication, potentially impacting processes associated with influenza virus, including the expression and function of HA. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine is an antioxidant and mucolytic agent with anti-inflammatory properties. While not directly affecting HA, NAC can influence host cell responses and inflammation, potentially impacting the overall course of influenza infection, including aspects related to the HA protein. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly I:C is a synthetic analog of double-stranded RNA that can activate innate immune responses. While not directly affecting HA, Poly I:C can modulate cellular responses to viral infections, influencing the overall antiviral state and potentially impacting influenza virus replication, including processes related to HA. | ||||||
Tilorone dihydrochloride | 27591-69-1 | sc-237108 | 100 mg | $102.00 | ||
Tilorone hydrochloride is an antiviral agent that can influence host cell responses to viral infections. While its specific impact on HA is indirect, tilorone hydrochloride may modulate cellular processes that contribute to the overall antiviral defense against influenza infection, affecting various stages of the viral life cycle. | ||||||