Date published: 2025-10-19

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Tilorone dihydrochloride (CAS 27591-69-1)

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Alternate Names:
DEAE-F
Application:
Tilorone dihydrochloride is A carbonyl compound is an antiviral for proteomics research
CAS Number:
27591-69-1
Purity:
≥98%
Molecular Weight:
483.47
Molecular Formula:
C25H34N2O32HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tilorone dihydrochloride is a synthetic compound primarily studied for its role in modulating biological responses. In research applications, it is often used to investigate the induction of interferon and other cytokines within the context of innate immunity. The compound serves as a tool to better understand the cellular signaling pathways involved in the antiviral response and the regulation of gene expression linked to the immune response. Additionally, Tilorone dihydrochloride is utilized in molecular biology to study the effects of small molecules on nucleic acid synthesis and function. Researchers may also employ Tilorone dihydrochloride in the examination of cell signaling and apoptosis due to its influence on various cellular processes. Furthermore, in the field of immunology, it contributes to the exploration of the mechanisms through which cells recognize and respond to foreign substances.


Tilorone dihydrochloride (CAS 27591-69-1) References

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  2. A clinical flow cytometric biomarker strategy: validation of peripheral leukocyte phospholipidosis using Nile red.  |  Halstead, BW., et al. 2006. J Appl Toxicol. 26: 169-77. PMID: 16278808
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  4. Effect of tilorone and its analogues on the change of mitochondrial potential of rat hepatocytes.  |  Zholobak, NM., et al. 2012. Fiziol Zh (1994). 58: 39-43. PMID: 22873051
  5. An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.  |  Zhang, J., et al. 2015. Molecules. 20: 21458-63. PMID: 26633340
  6. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.  |  Ekins, S., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29133569
  7. The effects of coadministration of tilorone dihydrochloride and culture supernatants from Lactobacillus reuteri on the mouse hepatoma cell line.  |  Alem, M., et al. 2019. J Cancer Res Ther. 15: 176-184. PMID: 30880776
  8. Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond.  |  Ekins, S., et al. 2020. Pharm Res. 37: 71. PMID: 32215760
  9. The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing Recommendation.  |  Gates, LE. and Hamed, AA. 2020. J Med Internet Res. 22: e21169. PMID: 32735546
  10. Tilorone-Dihydrochloride Protects against Rift Valley Fever Virus Infection and Disease in the Mouse Model.  |  Johnson, KN., et al. 2021. Microorganisms. 10: PMID: 35056541
  11. Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus.  |  Yang, J., et al. 2022. Virol Sin. 37: 145-148. PMID: 35234618
  12. Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers.  |  Kauffman, CA., et al. 1974. Infect Immun. 10: 212-5. PMID: 4546284
  13. Effects of ring substituents and linker chains on the bifunctional intercalation of diacridines into deoxyribonucleic acid.  |  Wright, RG., et al. 1980. Biochemistry. 19: 5825-36. PMID: 7193050

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tilorone dihydrochloride, 100 mg

sc-237108
100 mg
$100.00