H6PD Activators
The chemical class known as H6PD activators refers to a diverse group of compounds that possess the unique ability to enhance the activity of the enzyme 6-phosphogluconate dehydrogenase (H6PD). This enzyme is a key player in the pentose phosphate pathway, a vital metabolic pathway involved in glucose metabolism and the production of NADPH, an essential cofactor for various cellular processes. H6PD activators interact with the enzyme to promote its catalytic function, which leads to an increased conversion of 6-phosphogluconate to ribulose-5-phosphate, ultimately resulting in elevated NADPH levels. These activators may include naturally occurring molecules, synthetic compounds, or analogs that effectively modulate the enzymatic activity of H6PD. By promoting H6PD activity, these compounds hold the potential to impact cellular redox balance, lipid metabolism, and nucleotide synthesis, contributing to the intricate orchestration of cellular processes.
The intricate interplay between H6PD and its activators represents an important facet of cellular metabolism and offers insights into the regulation of biochemical pathways crucial for cellular homeostasis and function. As our understanding of enzyme regulation and metabolic networks advances, investigating H6PD activators may unveil new avenues for exploring the complex intricacies of cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Glucose 6-phosphate disodium salt | 3671-99-6 | sc-221488 sc-221488A sc-221488B | 10 mg 1 g 25 g | $39.00 $67.00 $1124.00 | 1 | |
G6P is a substrate for H6PD and is involved in its catalytic activity. Higher concentrations of G6P might act as an activator of H6PD by increasing its substrate availability. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
As an AMPK activator, it may indirectly influence H6PD by altering cellular energy metabolism. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPAR-gamma agonist, which may affect glucose metabolism pathways involving H6PD. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can modulate glucose metabolism, potentially influencing H6PD's role in glucocorticoid regeneration. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Another PPAR-gamma agonist, possibly affecting H6PD activity through alterations in glucose metabolism. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, thereby potentially influencing pathways that intersect with H6PD's function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A synthetic glucocorticoid that might impact H6PD indirectly through glucocorticoid metabolism pathways. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Another biguanide like Metformin, potentially affecting H6PD activity by altering cellular energy status. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, it could influence metabolic pathways intersecting with H6PD's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, it might impact H6PD indirectly through pathways associated with cellular growth and metabolism. | ||||||