H3.Y histone 1 Inhibitors
H3.Y histone 1 inhibitors represent a category of molecules that target a specific subtype of histone proteins, namely the H3.Y histone variant. Histones are fundamental components of chromatin, which forms the structural foundation of eukaryotic DNA packaging. They play a key role in regulating gene expression, as modifications to histones can influence how tightly or loosely DNA is wrapped around them. The H3.Y histone variant is a recently characterized member of the histone H3 family, distinguished by unique sequence elements that confer specific biological functions, including roles in chromatin dynamics and transcriptional regulation. This histone variant is not as ubiquitously expressed as canonical histone H3, but it has been found to be highly conserved across some species and exhibits tissue-specific expression patterns. Its distinctive structure presents a specific target for chemical modulation, which allows researchers to study its role in chromatin-related processes.
Inhibitors of H3.Y histone 1 typically interact with regions of the histone that are responsible for post-translational modifications, such as methylation or acetylation. By selectively inhibiting the activity or modification of H3.Y histones, these compounds can provide insight into how specific histone variants influence chromatin accessibility, gene silencing, and transcriptional activation. Furthermore, the structural diversity of H3.Y histone 1 inhibitors allows for fine-tuned modulation of chromatin states, thereby offering a valuable tool for probing epigenetic mechanisms. These inhibitors are typically characterized by their ability to disrupt the recognition or recruitment of chromatin-modifying complexes, thus affecting the histone's role in gene regulatory networks. The study of H3.Y histone 1 inhibitors offers a deeper understanding of histone variant functions, chromatin remodeling, and the broader implications of histone diversity in gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This hydroxamic acid derivative inhibits histone deacetylases (HDACs), leading to hyperacetylation of histones, including H3.Y histone 1. This hyperacetylation reduces the affinity of the histones for DNA, thereby inhibiting chromatin compaction and gene silencing typically associated with H3.Y histone 1. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
As an HDAC inhibitor, this compound promotes acetylation of histones, including H3.Y histone 1. Increased acetylation disrupts the normal function of H3.Y histone 1 in maintaining chromatin structure and regulating gene expression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
This potent pan-HDAC inhibitor leads to the accumulation of acetylated histones, such as H3.Y histone 1. This aberrant acetylation impairs the ability of H3.Y histone 1 to properly package DNA, thus indirectly inhibiting its role in transcriptional repression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
As an HDAC inhibitor, this agent increases the acetylation levels of histones, including H3.Y histone 1. This modification disrupts H3.Y histone 1-mediated chromatin condensation and gene regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
This HDAC inhibitor causes hyperacetylation of histone proteins, including H3.Y histone 1, which in turn leads to a more open chromatin structure and a loss of H3.Y histone 1-mediated transcriptional repression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
By inhibiting HDACs, this compound results in the hyperacetylation of histone proteins. Hyperacetylated H3.Y histone 1 cannot compact chromatin effectively, thereby inhibiting its role in gene silencing. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
This short-chain fatty acid is also an HDAC inhibitor. It leads to increased acetylation of histones, including H3.Y histone 1, which interferes with its function in chromatin remodeling and gene expression control. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate causes an increase in the acetylation of histones like H3.Y histone 1. The elevated acetylation level counteracts the transcriptional repression abilities of H3.Y histone 1. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $156.00 $572.00 | ||
An inhibitor of HDACs, this compound increases acetylation of histones. Enhanced acetylation of H3.Y histone 1 diminishes its capacity to condense chromatin and repress transcriptional activity. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $62.00 $250.00 $1196.00 | ||
As an HDAC inhibitor, chidamide promotes histone acetylation, decreasing the ability of H3.Y histone 1 to compact chromatin and regulate gene expression negatively. | ||||||