H2-T3 inhibitors belong to a specific class of chemical compounds meticulously designed to modulate the activity of the H2-T3 protein. H2-T3, also known as histocompatibility 2, T region locus 3, is a protein component of the major histocompatibility complex (MHC) system found in mice. The MHC system plays an essential role in the immune response by facilitating the presentation of antigenic peptides to T cells, a process that enables the immune system to recognize and mount responses against foreign pathogens. H2-T3, much like other MHC molecules, is intricately involved in the complex mechanism of antigen presentation, a fundamental process that allows the body to initiate immune responses against infections. The development of H2-T3 inhibitors is primarily motivated by the objective of selectively interacting with the H2-T3 protein, potentially influencing its antigen-presenting activity and impacting immune recognition processes.
Typically, H2-T3 inhibitors comprise small molecules or chemical compounds that are painstakingly engineered to bind to H2-T3, targeting either its active site or allosteric sites. This interaction has the potential to modulate H2-T3's behavior, potentially affecting its ability to present antigenic peptides to T cells and, consequently, influencing the immune response against foreign antigens. Researchers are committed to uncovering the molecular mechanisms and functions of H2-T3 within the MHC system, with the aim of gaining profound insights into the complex immune recognition processes. The development of H2-T3 inhibitors represents an ongoing and dynamic field of research within the realms of immunology and molecular pharmacology, contributing significantly to our understanding of the immune system's functioning and its role in detecting and responding to foreign antigens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA polymerase, which can downregulate gene expression including potentially H2-T3. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent inhibitor of RNA polymerase II, it could reduce the transcription of H2-T3 mRNA. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Known to inhibit the transcription of various genes and could decrease H2-T3 expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Can inhibit DNA and RNA synthesis and might affect H2-T3 mRNA levels. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic protein synthesis by interfering with the translocation step, potentially reducing H2-T3 protein levels. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Causes premature chain termination during protein synthesis, which could affect H2-T3 protein levels. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits eukaryotic protein synthesis, potentially reducing the expression of proteins like H2-T3. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, potentially affecting nucleotide synthesis and H2-T3 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to G-C rich regions of DNA, inhibiting the binding of transcription factors and thereby may decrease H2-T3 gene expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits DNA topoisomerase II, potentially affecting DNA replication and transcription, including H2-T3 expression. | ||||||