Date published: 2026-1-10

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H2-T3 Inhibitors

H2-T3 inhibitors belong to a specific class of chemical compounds meticulously designed to modulate the activity of the H2-T3 protein. H2-T3, also known as histocompatibility 2, T region locus 3, is a protein component of the major histocompatibility complex (MHC) system found in mice. The MHC system plays an essential role in the immune response by facilitating the presentation of antigenic peptides to T cells, a process that enables the immune system to recognize and mount responses against foreign pathogens. H2-T3, much like other MHC molecules, is intricately involved in the complex mechanism of antigen presentation, a fundamental process that allows the body to initiate immune responses against infections. The development of H2-T3 inhibitors is primarily motivated by the objective of selectively interacting with the H2-T3 protein, potentially influencing its antigen-presenting activity and impacting immune recognition processes.

Typically, H2-T3 inhibitors comprise small molecules or chemical compounds that are painstakingly engineered to bind to H2-T3, targeting either its active site or allosteric sites. This interaction has the potential to modulate H2-T3's behavior, potentially affecting its ability to present antigenic peptides to T cells and, consequently, influencing the immune response against foreign antigens. Researchers are committed to uncovering the molecular mechanisms and functions of H2-T3 within the MHC system, with the aim of gaining profound insights into the complex immune recognition processes. The development of H2-T3 inhibitors represents an ongoing and dynamic field of research within the realms of immunology and molecular pharmacology, contributing significantly to our understanding of the immune system's functioning and its role in detecting and responding to foreign antigens.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Binds to DNA and inhibits RNA polymerase, which can downregulate gene expression including potentially H2-T3.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

A potent inhibitor of RNA polymerase II, it could reduce the transcription of H2-T3 mRNA.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Known to inhibit the transcription of various genes and could decrease H2-T3 expression.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Can inhibit DNA and RNA synthesis and might affect H2-T3 mRNA levels.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Inhibits eukaryotic protein synthesis by interfering with the translocation step, potentially reducing H2-T3 protein levels.

Puromycin

53-79-2sc-205821
sc-205821A
10 mg
25 mg
$166.00
$322.00
436
(1)

Causes premature chain termination during protein synthesis, which could affect H2-T3 protein levels.

Anisomycin

22862-76-6sc-3524
sc-3524A
5 mg
50 mg
$99.00
$259.00
36
(2)

Inhibits eukaryotic protein synthesis, potentially reducing the expression of proteins like H2-T3.

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$69.00
$266.00
8
(1)

Inhibits inosine monophosphate dehydrogenase, potentially affecting nucleotide synthesis and H2-T3 expression.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

Binds to G-C rich regions of DNA, inhibiting the binding of transcription factors and thereby may decrease H2-T3 gene expression.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

Inhibits DNA topoisomerase II, potentially affecting DNA replication and transcription, including H2-T3 expression.