GTPBP8 Inhibitors
GTPBP8 Inhibitors are a diverse collection of chemical compounds that, through various mechanisms, lead to the inhibition of GTPBP8, a protein involved in mitochondrial protein synthesis. Compounds such as Allopurinol and 2-Deoxy-D-glucose target the purine synthesis and glycolysis pathways, respectively, leading to a reduced pool of GTP, which is essential for the GTP-binding function of GTPBP8. Similarly, inhibitors of mitochondrial ATP production like Oligomycin, Rotenone, Aurovertin B, Azide, and Dinitrophenol indirectly inhibit GTPBP8 by depleting the energy supply crucial for its role in mitochondrial translation. Chloramphenicol and Emetine, on the other hand, act directly on mitochondrial ribosomes, thereby impedingthe protein synthesis process in which GTPBP8 participates. By blocking the formation of mitochondrial proteins, these compounds indirectly diminish GTPBP8 activity by disrupting its functional context within the mitochondria.
Moreover, Tunicamycin induces ER stress that can interfere with mitochondrial functions, consequently affecting the activity of mitochondrial proteins like GTPBP8 through the ER-mitochondria interplay. Actinonin's inhibition of peptide deformylase hampers the initial steps of mitochondrial protein synthesis, again indirectly reducing GTPBP8's involvement in this process. Ethidium bromide's intercalation with mitochondrial DNA hinders the transcription of mitochondrial-encoded proteins, thereby indirectly limiting the functional scope of GTPBP8 by reducing its substrate availability. Collectively, these inhibitors employ a range of strategies to decrease the functional activity of GTPBP8, ultimately impacting mitochondrial protein synthesis by altering energy availability, directly inhibiting synthesis machinery, or disrupting associated biosynthetic pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Allopurinol | 315-30-0 | sc-207272 | 25 g | $128.00 | ||
Allopurinol is a xanthine oxidase inhibitor that reduces the production of uric acid. GTPBP8, which is involved in mitochondrial protein synthesis, may be indirectly inhibited by the reduction of guanine nucleotide pools, as xanthine oxidase is involved in the degradation pathway of purines to uric acid, which in turn could affect the guanine nucleotide availability for GTP-binding proteins such as GTPBP8. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation. While GTPBP8 is not glycosylated, tunicamycin-induced ER stress may perturb mitochondrial function by activating the unfolded protein response (UPR), which could indirectly diminish the activity of mitochondrial proteins including GTPBP8 due to cross-talk between the ER and mitochondria. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $175.00 $600.00 $1179.00 $5100.00 $9180.00 | 26 | |
Oligomycin is an inhibitor of the mitochondrial ATP synthase. By inhibiting ATP production, it may indirectly affect the energy-dependent processes such as the function of GTPBP8 in mitochondrial protein translation by depriving the necessary energy in the form of GTP. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose is a glycolysis inhibitor that can decrease ATP production. Lesser ATP availability can lead to reduced GTP levels through the purine nucleotide cycle, indirectly decreasing GTPBP8 activity, which relies on GTP for its function. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor. By disrupting mitochondrial electron transport, it decreases ATP production, which may indirectly lower GTPBP8 activity by affecting the overall mitochondrial protein synthesis machinery. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Chloramphenicol is a bacterial protein synthesis inhibitor that can also affect mitochondrial ribosomes due to their bacterial evolutionary origin. It may indirectly inhibit GTPBP8 by impairing mitochondrial protein synthesis, where GTPBP8 plays a role. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $160.00 $319.00 | 3 | |
Actinonin is an inhibitor of peptide deformylase, which is important for N-formylmethionine processing in newly synthesized proteins. In mitochondria, it can indirectly inhibit GTPBP8 by disrupting the initiation of mitochondrial protein synthesis. | ||||||
Ethidium bromide | 1239-45-8 | sc-203735 sc-203735A sc-203735B sc-203735C | 1 g 5 g 25 g 100 g | $47.00 $147.00 $576.00 $2045.00 | 12 | |
Ethidium bromide intercalates with DNA and can inhibit mitochondrial DNA transcription. This inhibition can indirectly affect GTPBP8 by reducing the expression of mitochondrial-encoded proteins that require GTPBP8 for their synthesis. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Azide is an inhibitor of mitochondrial complex IV. It disrupts ATP synthesis by halting the electron transport chain, which can indirectly inhibit GTPBP8 by reducing the energy supply necessary for its function in protein synthesis. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
Dinitrophenol uncouples oxidative phosphorylation, reducing ATP synthesis efficiency. This could indirectly impair GTPBP8 activity by decreasing the energy available in the mitochondria for protein synthesis. | ||||||