GSH-2 Inhibitors

The designation "GSH-2" is not a standard name for a protein and may be an abbreviation or shorthand for a protein related to glutathione metabolism. The most related concept to "GSH" in a biological context is glutathione, a tripeptide composed of glutamine, cysteine, and glycine, which is a critical antioxidant within cells, playing a vital role in cellular defense against oxidative stress.Glutathione exists in two forms: the reduced form (GSH) and the oxidized form (GSSG). The ratio of GSH to GSSG within cells is often used as a measure of cellular oxidative stress. Specific enzymes are responsible for maintaining the balance between these two forms, including glutathione reductase, which converts GSSG back to GSH.

In terms of "GSH-2," it's possible that this could be a reference to a specific enzyme or protein variant involved in glutathione metabolism, or it might be a term from a particular research study or proprietary nomenclature from a specific database. Without additional context, it's challenging to provide a definitive description.If "GSH-2" refers to a glutathione S-transferase (GST) isozyme, for example, it would be a member of a family of enzymes that catalyze the conjugation of the reduced form of glutathione to xenobiotic substrates for the purpose of detoxification. These enzymes play important roles in resistance to drugs and toxic chemicals, and multiple isozymes exist with varied tissue distributions and substrate specificities.