GSH-2 Activators

GSH-2, also known as GS Homeobox 2, is a protein that in humans is encoded by the GSX2 gene. Located on chromosome 20, this gene plays a crucial role in early development, especially in the formation of the central nervous system.The GSH-2 protein is a homeobox protein. Homeobox genes are a group of genes that share a common DNA sequence known as the homeobox. They are involved in controlling the development of organs and body structures.

GSH-2, specifically, is known to play a critical role in the development of the forebrain and the basal ganglia in mammals. It helps regulate the process of neurogenesis, where new neurons are created from neural stem or progenitor cells. This includes the differentiation of specific types of neurons and the formation of precise neural circuits.Mutations in the GSX2 gene have been associated with a variety of neurological abnormalities. Studies suggest that disruptions in GSX2 could lead to severe developmental disorders, including microcephaly (a condition where the head is significantly smaller than normal due to the brain not developing properly) and intellectual disability.While much is known about GSH-2's role in development, there's still much to learn about how it functions in the adult brain. It's unclear what role, if any, GSH-2 might play in the maintenance of neuronal populations in the adult brain, or in neurological disorders that strike in adulthood.