GSBS Activators
GSBS activators belong to a niche category within the chemical realm, characterized by their ability to interact specifically with the GSBS (Guanine nucleotide-binding protein-coupled bile acid receptor) system. This system is an intricate network of receptors and proteins that respond to the presence of certain chemical signals, particularly those related to bile acids, which are substances synthesized from cholesterol in the liver. The GSBS activators, through their tailored molecular configuration, can effectively modulate the functioning of these receptors. These activators typically feature a sophisticated molecular design that allows them to bind with high specificity and efficacy to their target sites, thereby influencing the receptor's natural activity.
The role of GSBS activators is fundamentally rooted in the modulation of receptor behavior, which is a critical aspect of the molecular communication pathways within cells. These activators are designed to bind to the GSBS receptors and induce a conformational change, which can lead to an alteration in the activity of the receptor. This binding can either increase or stabilize the active state of the receptor, leading to a cascade of intracellular events. The precise molecular structure of GSBS activators is crucial as it determines their affinity for the receptor and the degree to which they can alter the receptor's activity. This structural specificity is achieved through a careful selection of atoms and functional groups that can engage with the receptor's active site, often involving a combination of hydrogen bonding, hydrophobic interactions, and van der Waals forces to secure a stable interaction. The study of GSBS activators is a fine example of the intricate dance between chemical structure and biological function, showcasing the deep interconnection between chemistry and the subtleties of molecular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin serves as an activator of adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP can activate protein kinase A (PKA), which then can phosphorylate and activate GSBS, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, or 3-Isobutyl-1-methylxanthine, is a non-selective inhibitor of phosphodiesterases, thus preventing the breakdown of cAMP and cGMP. This leads to higher intracellular levels of these cyclic nucleotides, which could enhance PKA activity, subsequently stimulating GSBS activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known as a potent antioxidant that can modulate kinase pathways. By inhibiting certain kinases, it may release GSBS from inhibitory constraints, thus enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC), which can phosphorylate a wide array of substrates, potentially including those that interact with or activate GSBS. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase, leading to the production of nitric oxide (NO), which can activate soluble guanylyl cyclase and increase cGMP levels, indirectly promoting GSBS activation through PKG signaling. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $516.00 $720.00 $16326.00 | 7 | |
Vardenafil, like sildenafil, is a PDE5 inhibitor, which increases cGMP levels and can enhance PKG activity, potentially influencing GSBS activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is another PDE5 inhibitor that also has a selective inhibitory effect on PDE9, leading to elevated levels of cGMP and thereby potentially enhancing GSBS activity through PKG signaling. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels, which may enhance PKA signaling and subsequently GSBS activity. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits PDE3, leading to increased cAMP levels, which could in turn enhance PKA activity and GSBS activation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide acts as an inhibitor of sirtuins, which can influence a variety of cellular processes including the deacetylation of proteins. This may indirectly affect the activation state or function of GSBS. | ||||||