Grx1 Inhibitors
Grx1 Inhibitors, as outlined in the table above, comprise a diverse group of compounds primarily focused on modulating the cellular redox state, thereby indirectly influencing Grx1 activity. These inhibitors are not direct antagonists of Grx1 but operate by altering the oxidative stress levels or the redox balance within the cell. This alteration in the cellular environment can affect the activity of redox-sensitive enzymes like Grx1.
The mechanisms of action of these inhibitors vary. Some, like Auranofin, target other enzymes in the redox regulation pathway (e.g., thioredoxin reductase), while others, such as Cisplatin and Arsenic Trioxide, induce oxidative stress through different mechanisms. Disulfiram and Selenium Compounds exert their effects by modulating key elements in the redox system, such as copper and selenium. Compounds like Buthionine Sulfoximine and Methylglyoxal influence Grx1 activity by depleting essential redox buffers or modifying proteins, respectively. Furthermore, the introduction of oxidative stress by compounds such as Tert-Butyl Hydroperoxide, Menadione, and natural antioxidants like Curcumin, Sulforaphane, and Epigallocatechin Gallate highlights the intricate balance of redox regulation in cells. These compounds demonstrate the indirect approach to modulating Grx1 activity, either by elevating reactive oxygen species levels or by enhancing the cellular antioxidant response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing compound known to inhibit thioredoxin reductase, another key player in cellular redox regulation. Its inhibition can indirectly affect Grx1 activity by altering the cellular redox state. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a platinum-based compound, forms DNA adducts and generates oxidative stress, potentially influencing Grx1 function by altering the redox environment. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram, primarily used in alcohol aversion therapy, can chelate copper and inhibit superoxide dismutase, thereby affecting the redox balance and indirectly Grx1 activity. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide, used in cancer therapy, can induce oxidative stress and affect the redox-sensitive pathways, indirectly impacting Grx1. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $286.00 $442.00 $1532.00 $2975.00 | 26 | |
This compound inhibits glutathione synthesis, reducing the major cellular antioxidant and altering redox balance, potentially affecting Grx1 function. | ||||||
Methylglyoxal solution | 78-98-8 | sc-250394 sc-250394A sc-250394B sc-250394C sc-250394D | 25 ml 100 ml 250 ml 500 ml 1 L | $146.00 $437.00 $478.00 $754.00 $1446.00 | 3 | |
Methylglyoxal is a glycolysis by-product that can modify protein functions through glycation, potentially impacting Grx1 activity. | ||||||
tert-Butyl hydroperoxide aqueous solution | 75-91-2 | sc-251134 sc-251134A | 100 ml 500 ml | $46.00 $100.00 | 1 | |
This organic peroxide induces oxidative stress, potentially influencing Grx1 activity by altering the cellular redox state. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Menadione generates reactive oxygen species, thereby affecting redox-sensitive enzymes like Grx1. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Found in cruciferous vegetables, sulforaphane influences cellular antioxidant responses, potentially impacting Grx1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major component of green tea, it has antioxidant properties and can affect the cellular redox state, potentially impacting Grx1 activity. | ||||||