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tert-Butyl hydroperoxide aqueous solution (CAS 75-91-2)

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Alternate Names:
TBHP
CAS Number:
75-91-2
Molecular Weight:
90.12
Molecular Formula:
C4H10O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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tert-Butyl hydroperoxide solution, an organic peroxide, finds extensive utility in numerous oxidation processes. This compound, characterized by its tert-butyl alkyl group, serves as a versatile tool in diverse oxidation reactions. With its dual role as an antibacterial agent and an oxidizing agent, tert-butyl hydroperoxide offers a broad range of applications. Notably, it has been observed to play a significant role in peroxynitrite-dependent PC12 cell necrosis, a process associated with the peroxidation of membrane lipids and the induction of mitochondrial permeability transition. In this context, tert-butyl hydroperoxide acts as a promoter, facilitating the development of the aforementioned cell necrosis through its involvement in oxidative processes.


tert-Butyl hydroperoxide aqueous solution (CAS 75-91-2) References

  1. Reversed-phase high-performance liquid chromatographic separation of tert.-butyl hydroperoxide oxidation products of unsaturated triacylglycerols.  |  Sjovall, O., et al. 2001. J Chromatogr A. 905: 119-32. PMID: 11206778
  2. Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro.  |  Awe, SO. and Adeagbo, AS. 2002. Life Sci. 71: 1255-66. PMID: 12106591
  3. The influence of the solvent on the epoxidation of cis,trans,trans-1,5,9-cyclododecatriene to trans-1,2-epoxy-cis,trans-5,9-cyclododecadiene by catalytic system tert-butyl hydroperoxide/Mo(CO)6.  |  Lewandowski, G., et al. 2005. J Hazard Mater. 120: 45-50. PMID: 15811663
  4. Physiological effects of tert-butyl hydroperoxide on the rabbit corneal epithelium.  |  Kwok, LS. and Klyce, SD. 1992. CLAO J. 18: 97-100. PMID: 1606682
  5. Diruthenium(II,III) bis(tetramethyl-1,3-benzenedipropionate) as a novel catalyst for tert-butyl hydroperoxide oxygenation.  |  Barker, JE. and Ren, T. 2008. Inorg Chem. 47: 2264-6. PMID: 18338851
  6. Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.  |  Dutot, M., et al. 2008. Mol Vis. 14: 889-97. PMID: 18490962
  7. Effect of vitamin C, deferoxamine, quercetin and rutin against tert-butyl hydroperoxide oxidative damage in human erythrocytes.  |  Krukoski, DW., et al. 2009. Hematology. 14: 168-72. PMID: 19490763
  8. Effect of thiol drugs on tert-butyl hydroperoxide induced luminol chemiluminescence in human erythrocytes, erythrocyte lysate, and erythrocyte membranes.  |  Sajewicz, W. 2010. Chem Biol Interact. 186: 144-51. PMID: 20430017
  9. One-Pot Magnetic Iron Oxide-Carbon Nanodot Composite-Catalyzed Cyclooxidative Aqueous Tandem Synthesis of Quinazolinones in the Presence of tert-Butyl Hydroperoxide.  |  Majumdar, B., et al. 2018. ACS Omega. 3: 13711-13719. PMID: 31458072
  10. Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest.  |  Lee, HA., et al. 2020. Exp Parasitol. 210: 107833. PMID: 31935358
  11. CREB Ameliorates Osteoarthritis Progression Through Regulating Chondrocytes Autophagy via the miR-373/METTL3/TFEB Axis.  |  Zhang, H., et al. 2021. Front Cell Dev Biol. 9: 778941. PMID: 35756079
  12. Solution-Phase Chemical Synthesis of Modified RNA Dinucleotides.  |  Senthilvelan, A., et al. 2022. Curr Protoc. 2: e583. PMID: 36342272
  13. tert.-butyl hydroperoxide-mediated DNA base damage in cultured mammalian cells.  |  Altman, SA., et al. 1994. Mutat Res. 306: 35-44. PMID: 7512201
  14. Modulating role of endogenous reduced glutathione in tert-butyl hydroperoxide-induced cell injury in isolated rat hepatocytes.  |  Nishida, K., et al. 1997. Free Radic Biol Med. 23: 453-62. PMID: 9214582

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

tert-Butyl hydroperoxide aqueous solution, 100 ml

sc-251134
100 ml
$46.00

tert-Butyl hydroperoxide aqueous solution, 500 ml

sc-251134A
500 ml
$100.00

Dear SCBT, Due to safety reasons, I would need to order a very small quantity of tBHP in stead of the large volumes that are advertised. Would it be possible to prepare a 1-5 mL quantity of tBHP? Best wishes,

Asked by: Irini92
Thank you for your question. Unfortunately, we are unable to offer the quantity you are requesting.
Answered by: Tech Support Europe
Date published: 2021-01-25
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Rated 5 out of 5 by from ZhangZhang, et al. (PubMed ID 26389527) utilized tert-butyl hydroperoxide (t-BHP) as an oxidative agent in a comparison study between wild type and yeast yap1 mutant. -SCBT Publication Review
Date published: 2015-06-13
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tert-Butyl hydroperoxide aqueous solution is rated 5.0 out of 5 by 1.
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