group V PLA2 Inhibitors
Group V PLA2 inhibitors are a chemically heterogeneous group of organic compounds that have been identified for their distinctive ability to modulate the enzymatic action of Group V secretory phospholipase A2 (PLA2). These inhibitors display a remarkable specificity in their interaction with key binding sites within the active site region of the Group V PLA2 enzyme or adjacent areas that are pivotal for substrate recognition. This engagement generally involves intricate structural elements that align with complementary regions on the enzyme surface. These inhibitors vary widely in their structural scaffolds, encompassing diverse arrangements of aromatic rings, aliphatic chains, and functional groups, all of which contribute to their binding affinity and inhibitory potency.
By selectively engaging with the active site or closely associated regions of Group V PLA2, these inhibitors disrupt the hydrolytic cleavage of phospholipids present in cell membranes. This disruption significantly impedes the liberation of arachidonic acid, a vital fatty acid precursor instrumental in the biosynthesis of various lipid mediators, including prostaglandins and leukotrienes, known for their potent roles in modulating inflammation, immunity, and cellular signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
While not a direct inhibitor of Group V PLA2, pefabloc is a serine protease inhibitor that can also inhibit certain types of PLA2 enzymes, including some Group V enzymes. | ||||||
Manoalide | 75088-80-1 | sc-200733 | 1 mg | $269.00 | 9 | |
Manoalide is a marine natural product that exhibits inhibitory effects on multiple PLA2 isoforms, including Group V. | ||||||
OBAA | 134531-42-3 | sc-202748 | 5 mg | $98.00 | 3 | |
2-Octadecylamino-4-[(3-bromophenyl)amino]-4-oxobutanoic acid (OBAA) is a compound that has shown inhibition of Group IIA, Group V, and Group X PLA2 isoforms. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein is a flavonoid compound found in certain plants, and it has been shown to inhibit multiple PLA2 isoforms, including Group V. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric, and it has been reported to have inhibitory effects on various PLA2 enzymes, including Group V. | ||||||
MK-886 sodium salt | 118427-55-7 | sc-200608B sc-200608 sc-200608A | 1 mg 5 mg 25 mg | $47.00 $95.00 $378.00 | 3 | |
While primarily known as a 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886 has also been reported to inhibit PLA2 enzymes, including Group V. | ||||||