group V PLA2 Activators
Group V PLA2 Activators are a set of compounds that indirectly stimulate the functional activity of group V PLA2, a protein involved in intricate lipid signaling and metabolic pathways. The activators, through distinct biochemical interactions, ensure an increased activity of group V PLA2 by influencing the availability and demand for its substrates and products. Arachidonic Acid and Lysophosphatidylcholine directly supply the substrates required for the catalytic action of group V PLA2, bolstering the enzyme's activity. Bromoenol lactone selectively inhibits competing enzymes, which indirectly enhances group V PLA2 function by reducing substrate competition. Prostaglandin E2 and Leukotriene B4, metabolites in the arachidonic acid pathway, upregulate inflammatory responses and cellular processes that rely on group V PLA2's lipid hydrolysis, thereby increasing its activity. Compounds like Platelet-Activating Factor and its hydrolysis product, LysoPAF, propagate a feedback loop that amplifies group V PLA2's role in producing bioactive lipids.
Furthermore, A23187 facilitates group V PLA2 activity by increasing intracellular calcium, a crucial co-factor for the enzyme, while Phosphatidic Acid and Sphingosine-1-phosphate, through their roles as secondary messengers, indirectly influence group V PLA2 activity by modulating lipid signaling networks. Oleic Acid, by altering membrane fluidity, increases the availability of phospholipid substrates for group V PLA2, further enhancing its enzymatic action. U46619, mimicking the function of Prostaglandin H2, engages thromboxane A2 receptors and potentially escalates the activity of group V PLA2 in the production of thromboxane, an eicosanoid involved in vasoconstriction and platelet aggregation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a substrate for group V PLA2, arachidonic acid can enhance the enzyme's activity by providing the necessary substrate for its lipid hydrolysis reaction, which is the primary function of group V PLA2. | ||||||
L-α-Lysophosphatidylcholine (from egg yolk) | 9008-30-4 | sc-473611 sc-473611A sc-473611B sc-473611C | 25 mg 100 mg 500 mg 1 g | $87.00 $235.00 $607.00 $1102.00 | 1 | |
Lysophosphatidylcholine results from the action of group V PLA2 on phosphatidylcholine and can act as a positive feedback mechanism, enhancing the functional activity of group V PLA2 by increasing substrate availability. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
As a product of arachidonic acid metabolism, Prostaglandin E2 can indirectly increase the activity of group V PLA2 by upregulating processes that demand its substrate, arachidonic acid, thereby potentiating the enzyme's catalytic cycle. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
Leukotriene B4, another metabolite of arachidonic acid, can stimulate inflammatory pathways that necessitate the hydrolytic activity of group V PLA2, thus indirectly enhancing its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This ionophore increases intracellular calcium levels, indirectly enhancing group V PLA2 activity since the enzyme requires calcium for its catalytic activity. | ||||||
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $106.00 $244.00 $417.00 | ||
Phosphatidic Acid can serve as a secondary messenger in signaling pathways, and its production can be influenced by the action of group V PLA2, leading to enhanced group V PLA2 activity through complex lipid signaling networks. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This signaling lipid is involved in a variety of cellular processes and can modulate the activity of group V PLA2 indirectly by altering the cell's demand for lipid mediators, which are products of group V PLA2. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
As a bioactive lipid that can be synthesized from the products of group V PLA2 activity, Platelet-Activating Factor can upregulate inflammatory responses that, in turn, require the heightened enzymatic activity of group V PLA2. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid can increase the membrane fluidity and availability of glycerophospholipids, which are substrates for group V PLA2, thereby indirectly enhancing the enzyme's activity. | ||||||
U-46619 | 56985-40-1 | sc-201242 sc-201242A | 1 mg 10 mg | $245.00 $1301.00 | 40 | |
This synthetic analog of Prostaglandin H2 acts on thromboxane A2 receptors and can potentiate the role of group V PLA2 in producing eicosanoids, thereby enhancing its functional activity. | ||||||