group IIC sPLA2 Activators
Group IIC sPLA2 Activators are a diverse collection of chemical compounds that facilitate the enhancement of the enzyme's lipid hydrolysis function through various biochemical mechanisms. Arachidonic acid and phosphatidylserine are direct substrates for Group IIC sPLA2, and their increased presence in the cellular environment can naturally augment the functional activity of the enzyme. Furthermore, lysophosphatidylcholine can amplify Group IIC sPLA2 activity by modifying membrane dynamics, thereby facilitating access to phospholipid substrates. Sphingosine-1-phosphate (S1P) and calcium ionophore A23187 play critical roles in modulating membrane-associated signaling and calcium levels, respectively, both of which are essential for the optimal interaction of Group IIC sPLA2 with its substrates.
Bromoenol lactone (BEL) selectively inhibits iPLA2, potentially leading to a compensatory increase in Group IIC sPLA2 activity to maintain lipid metabolism equilibrium. Prostaglandin E2 (PGE2) and Platelet-activating factor (PAF) act through feedback mechanisms that enhance the enzyme's function by ensuring a steady supply of arachidonic acid and facilitating enzyme-substrate interaction at the membrane. Additionally, Leukotriene B4 (LTB4) can indirectly promote Group IIC sPLA2 activity by stimulating leukocyte functions that increase the demand for eicosanoid products, thereby driving the enzyme's activity. The peptide melittin, known for its ability to activate various phospholipases, enhances Group IIC sPLA2 activity by disrupting cell membranes, which increases the accessibility of lipid substrates. In contrast, Methyl arachidonyl fluorophosphonate (MAFP), despite its inhibitory effects on other sPLA2 isoforms, may indirectly upregulate Group IIC sPLA2 activity as a compensatory response to maintain lipid signaling pathways. Finally, Cytidine 5'-diphosphocholine (CDP-choline) is involved in the biosynthesis of phospholipids, potentially leading to an increase in substrate availability for Group IIC sPLA2, thereby facilitating its enzymatic action.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a substrate for Group IIC sPLA2, arachidonic acid availability can enhance the enzyme's activity by providing the necessary lipid molecules for hydrolysis, leading to the production of pro-inflammatory eicosanoids which indicates higher enzymatic activity of Group IIC sPLA2. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylserine serves as a specific substrate for Group IIC sPLA2, and its presence in the outer leaflet of the cell membrane can increase the catalytic activity of Group IIC sPLA2, thereby facilitating the release of arachidonic acid. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P can modulate cellular signaling pathways that may indirectly upregulate the activity of Group IIC sPLA2 by promoting membrane remodeling and providing access to phospholipid substrates. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
This compound increases intracellular calcium concentration, which is essential for the catalytic activity of Group IIC sPLA2 by facilitating the enzyme's binding to the membrane substrate. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can function in an autocrine or paracrine manner to enhance Group IIC sPLA2 activity through its positive feedback on the arachidonic acid cascade and facilitation of substrate availability. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF can induce cellular responses that may lead to the translocation of Group IIC sPLA2 to the membrane, where it can interact with its substrates more efficiently. | ||||||
LTB4 (Leukotriene B4) | 71160-24-2 | sc-201043 | 50 µg | $374.00 | 4 | |
LTB4 is involved in leukocyte recruitment and activation, which may indirectly stimulate Group IIC sPLA2 activity by increasing the demand for eicosanoid production. | ||||||
Melittin | 37231-28-0 | sc-200868 sc-200868A sc-200868B | 500 µg 1 mg 10 mg | $196.00 $339.00 $787.00 | 2 | |
As a peptide from bee venom known to activate phospholipases, melittin can enhance Group IIC sPLA2 activity by disrupting the cellular membrane and making substrates more accessible. | ||||||
MAFP | 188404-10-6 | sc-203440 | 5 mg | $219.00 | 4 | |
While MAFP is a known inhibitor of other sPLA2 isoenzymes, its action could lead to an indirect upregulation of Group IIC sPLA2 activity to compensate for the inhibition of other isoforms. | ||||||